SCHEMBL6590973

SCHEMBL6590973

Cc1ccc(NC(=O)c2scc(S(=O)(=O)C(C)C)c2Cl)c(C(=O)Nc2ccc(Cl)cc2)c1

nearest known ligand 0.80

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
F10 P00742 16/20 0.80
POLB P06746 1/20 0.55
MAPT P10636 1/20 0.53
MAPK1 P28482 1/20 0.53
F2 P00734 1/20 0.53
KDM4E B2RXH2 1/20 0.51
GAA P10253 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6592528 0.89 F10 (1.00) F10F2
SCHEMBL8014086 0.85 F10 (0.78) F10F2
SCHEMBL6592082 0.82 F10 (0.72) F10F2
SCHEMBL6592665 0.77 F10 (1.00) F10F2
SCHEMBL6588446 0.76 F10 (1.00) F10MAPTGAA
SCHEMBL6591493 0.76 F10 (0.69) F10F2
SCHEMBL6590874 0.75 F10 (1.00) F10F2
SCHEMBL6589930 0.74 F10 (0.80) F10MAPT
SCHEMBL7683846 0.74 F10 (0.61) F10F2
SCHEMBL6593733 0.73 F10 (1.00) F10F2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1040108-B1 ORTHO-ANTHRANILAMIDE DERIVATIVES AS ANTI-COAGULANTS SCHERING AG (DE) 2004-02-25 EP claimed
US-6498185-B1 ENZYME FACTOR XA INHIBITORS BERLEX LABORATORIES, INC. 2002-12-24 US claimed
EP-1040108-B1 ORTHO-ANTHRANILAMIDE DERIVATIVES AS ANTI-COAGULANTS SCHERING AG (DE) 2004-02-25 EP disclosed
US-6498185-B1 ENZYME FACTOR XA INHIBITORS BERLEX LABORATORIES, INC. 2002-12-24 US disclosed
US-6380221-B1 FOR THERAPY OF DISEASE-STATES CHARACTERIZED BY THROMBOTIC ACTIVITY BERLEX LABORATORIES, INC. 2002-04-30 US disclosed
US-6140351-A FOR TREATING THROMBOSIS BERLEX LABORATORIES, INC. (US) 2000-10-31 US disclosed