Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 5/20 | 0.57 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.57 |
| ▸ | SRC | P12931 | 3/20 | 0.57 |
| ▸ | PIM1 | P11309 | 2/20 | 0.57 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.57 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.57 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.57 |
| ▸ | FLT4 | P35916 | 1/20 | 0.57 |
| ▸ | CLK2 | P49760 | 1/20 | 0.57 |
| ▸ | GSK3A | P49840 | 1/20 | 0.57 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.57 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.57 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.57 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.57 |
| ▸ | PARP1 | P09874 | 5/20 | 0.48 |
| ▸ | FGFR1 | P11362 | 6/20 | 0.43 |
| ▸ | AURKA | O14965 | 2/20 | 0.43 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.42 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.42 |
| ▸ | FLT3 | P36888 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6591260 | 0.89 | KDR (0.57) | KDRAURKBSRCPIM1PIM3 | |
| SCHEMBL6585214 | 0.88 | AURKB (0.54) | KDRAURKBSRCPIM1PIM3 | |
| SCHEMBL6806475 | 0.87 | AURKB (0.74) | KDRAURKBSRCPIM1PIM3 | |
| SCHEMBL6588006 | 0.86 | AURKB (0.54) | KDRAURKBSRCPIM1PIM3 | |
| SCHEMBL6591474 | 0.86 | AURKB (0.77) | KDRAURKBSRCPIM1PIM3 | |
| SCHEMBL6591524 | 0.84 | AURKB (0.55) | KDRAURKBSRCPIM1PIM3 | |
| SCHEMBL6586626 | 0.83 | PIM1 (0.54) | KDRAURKBSRCPIM1PIM3 | |
| SCHEMBL6585555 | 0.83 | AURKB (0.50) | KDRAURKBSRCPIM1PIM3 | |
| SCHEMBL6591233 | 0.83 | AURKB (0.51) | KDRAURKBSRCPIM1PIM3 | |
| SCHEMBL6589590 | 0.81 | PIM1 (0.47) | KDRAURKBPIM1PIM3MKNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1177178-B1 | HETEROCYCLICALLY SUBSTITUTED BENZIMIDAZOLES, THE PRODUCTION AND APPLICATION THEREOF | ABBOTT GMBH & CO KG (DE) | 2004-12-29 | — | — | EP | disclosed |