Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EHMT2 | Q96KQ7 | 9/20 | 0.44 |
| ▸ | KIT | P10721 | 1/20 | 0.41 |
| ▸ | ACP1 | P24666 | 7/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | ABL2 | P42684 | 1/20 | 0.40 |
| ▸ | EHMT1 | Q9H9B1 | 1/20 | 0.40 |
| ▸ | AXL | P30530 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | MERTK | Q12866 | 1/20 | 0.40 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6336434 | 0.89 | EHMT2 (0.44) | EHMT2KITACP1ABL1SRC | |
| SCHEMBL6338533 | 0.86 | SRC (0.51) | EHMT2KITABL1SRCABL2 | |
| SCHEMBL6336695 | 0.85 | ACP1 (0.41) | EHMT2KITACP1ABL1SRC | |
| SCHEMBL6337390 | 0.82 | KDM4E (0.46) | EHMT2KITACP1 | |
| SCHEMBL6344436 | 0.79 | SRC (0.47) | EHMT2KITABL1SRCABL2 | |
| SCHEMBL6343097 | 0.79 | ACP1 (0.42) | EHMT2KITACP1AXLFLT3 | |
| SCHEMBL14155221 | 0.78 | ENPP1 (0.48) | EHMT2SRCEHMT1 | |
| SCHEMBL6986140 | 0.77 | KDR (0.48) | EHMT2KITAXLFLT3MERTK | |
| SCHEMBL4593476 | 0.77 | ENPP1 (0.59) | EHMT2KITAXLFLT3MERTK | |
| SCHEMBL4590452 | 0.77 | ENPP1 (0.59) | EHMT2KITAXLFLT3MERTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1490362-A2 | (HOMO)PIPERAZINE SUBSTITUTED QUINOLINES FOR INHIBITING THE PHOSPHORYLATION OF KINASES | Millennium Pharmaceuticals, Inc. (US) | 2004-12-29 | — | — | EP | disclosed |
| WO-2002072578-A2 | (HOMO) PIPERAZINE SUBSTITUTED QUINOLINES FOR INHIBITING THE PHOSPHORYLATION OF KINASES | MILLENNIUM PHARMACEUTICALS (US) | 2002-09-19 | — | — | WO | disclosed |