SCHEMBL6592290

SCHEMBL6592290

COCCN(CCOC)c1cc(Cl)cc(C(=O)Nc2ccc(Cl)cn2)c1NC(=O)c1scc(CN(C)CCO)c1Cl

nearest known ligand 0.80

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
F2 P00734 19/20 0.80
F10 P00742 18/20 0.80
KLKB1 P03952 1/20 0.58
ELANE P08246 1/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6593466 0.90 F2 (0.87) F2F10KLKB1ELANE
SCHEMBL6590340 0.89 F2 (0.65) F2F10KLKB1ELANE
SCHEMBL6590680 0.89 F2 (1.00) F2F10KLKB1ELANE
SCHEMBL6591245 0.87 F2 (0.82) F2F10KLKB1ELANE
SCHEMBL6587464 0.86 F2 (0.87) F2F10KLKB1ELANE
SCHEMBL6593541 0.85 F2 (0.74) F2F10
SCHEMBL6592257 0.84 F2 (1.00) F2F10KLKB1ELANE
SCHEMBL6591191 0.84 F2 (0.87) F2F10KLKB1ELANE
SCHEMBL6590477 0.84 F2 (0.84) F2F10KLKB1ELANE
SCHEMBL6591951 0.84 F2 (0.79) F2F10KLKB1ELANE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1040108-B1 ORTHO-ANTHRANILAMIDE DERIVATIVES AS ANTI-COAGULANTS SCHERING AG (DE) 2004-02-25 EP claimed
EP-1040108-B1 ORTHO-ANTHRANILAMIDE DERIVATIVES AS ANTI-COAGULANTS SCHERING AG (DE) 2004-02-25 EP disclosed
US-6498185-B1 ENZYME FACTOR XA INHIBITORS BERLEX LABORATORIES, INC. 2002-12-24 US disclosed
US-6380221-B1 FOR THERAPY OF DISEASE-STATES CHARACTERIZED BY THROMBOTIC ACTIVITY BERLEX LABORATORIES, INC. 2002-04-30 US disclosed
US-6140351-A FOR TREATING THROMBOSIS BERLEX LABORATORIES, INC. (US) 2000-10-31 US disclosed