Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 7/20 | 0.42 |
| ▸ | ACP1 | P24666 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | EHMT2 | Q96KQ7 | 3/20 | 0.40 |
| ▸ | KIT | P10721 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6337390 | 0.91 | KDM4E (0.46) | DPP4ACP1KDM4EALDH1A1NPSR1 | |
| SCHEMBL6343097 | 0.90 | ACP1 (0.42) | ACP1EHMT2KITPDGFRBIRAK4 | |
| SCHEMBL6336695 | 0.82 | ACP1 (0.41) | ACP1EHMT2KITPDGFRBIRAK4 | |
| SCHEMBL6336770 | 0.81 | KDM4E (0.40) | DPP4ACP1KDM4EEHMT2 | |
| SCHEMBL6344436 | 0.81 | SRC (0.47) | EHMT2KIT | |
| SCHEMBL22589588 | 0.80 | DPP4 (0.53) | DPP4NPSR1PDGFRB | |
| SCHEMBL29409636 | 0.80 | DPP4 (0.53) | DPP4NPSR1PDGFRB | |
| SCHEMBL6202289 | 0.79 | DPP4 (0.60) | DPP4NPSR1PDGFRB | |
| SCHEMBL28319922 | 0.78 | DPP4 (0.61) | DPP4ALDH1A1NPSR1PDGFRB | |
| SCHEMBL6334457 | 0.78 | PDGFRB (0.59) | KITPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1490362-A2 | (HOMO)PIPERAZINE SUBSTITUTED QUINOLINES FOR INHIBITING THE PHOSPHORYLATION OF KINASES | Millennium Pharmaceuticals, Inc. (US) | 2004-12-29 | — | — | EP | disclosed |
| WO-2002072578-A2 | (HOMO) PIPERAZINE SUBSTITUTED QUINOLINES FOR INHIBITING THE PHOSPHORYLATION OF KINASES | MILLENNIUM PHARMACEUTICALS (US) | 2002-09-19 | — | — | WO | disclosed |