Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 19/20 | 1.00 |
| ▸ | CDK4 | P11802 | 7/20 | 0.71 |
| ▸ | CDK1 | P06493 | 2/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.51 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.51 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.51 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.51 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.51 |
| ▸ | CCND1 | P24385 | 1/20 | 0.51 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.51 |
| ▸ | CCND3 | P30281 | 1/20 | 0.51 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.51 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.51 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.51 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.51 |
| ▸ | GSK3A | P49840 | 1/20 | 0.51 |
| ▸ | GSK3B | P49841 | 1/20 | 0.51 |
| ▸ | CDK7 | P50613 | 1/20 | 0.51 |
| ▸ | CDK9 | P50750 | 1/20 | 0.51 |
| ▸ | CCNH | P51946 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27533851 | 0.89 | CDK2 (0.81) | CDK2CDK4CDK1KCNH2CCNT1 | |
| SCHEMBL4818566 | 0.83 | CDK2 (1.00) | CDK2CDK4CDK1 | |
| SCHEMBL6598372 | 0.83 | CDK2 (0.77) | CDK2CDK4CDK1KCNH2CCNT1 | |
| SCHEMBL6593918 | 0.82 | CDK2 (0.90) | CDK2CDK4CDK1KCNH2CCNT1 | |
| SCHEMBL5105293 | 0.81 | CDK2 (0.77) | CDK2CDK4CDK1KCNH2CCNT1 | |
| SCHEMBL6103727 | 0.80 | CDK2 (0.81) | CDK2CDK4CDK1KCNH2CCNT1 | |
| SCHEMBL6595895 | 0.80 | CDK2 (0.81) | CDK2CDK4CDK1KCNH2CCNT1 | |
| SCHEMBL6595042 | 0.80 | CDK2 (0.66) | CDK2CDK4CDK1KCNH2CCNT1 | |
| SCHEMBL6296195 | 0.80 | CDK2 (0.66) | CDK2CDK4CDK1KCNH2CCNT1 | |
| SCHEMBL6594277 | 0.80 | CDK2 (0.66) | CDK2CDK4CDK1KCNH2CCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1351958-B1 | IMIDAZOLO-5-YL-2-ANILINO-PYRIMIDINES AS AGENTS FOR THE INHIBITION OF THE CELL PROLIFERATION | ASTRAZENECA AB (SE) | 2004-06-16 | — | — | EP | disclosed |