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SCHEMBL6594162

SCHEMBL6594162

COC(=O)N(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C1CC(C)N(C(=O)OCC(C)C)c2cc(OC)c(OC)cc21

nearest known ligand 0.56

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
▸ CETP P11597 20/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6594159 1.00 CETP (0.56) CETP
SCHEMBL6593045 0.93 CETP (0.55) CETP
SCHEMBL6593047 0.93 CETP (0.55) CETP
SCHEMBL6592772 0.92 CETP (0.66) CETP
SCHEMBL6593651 0.92 CETP (0.66) CETP
SCHEMBL993479 0.92 CETP (0.66) CETP
SCHEMBL6064661 0.91 CETP (0.58) CETP
SCHEMBL993012 0.91 CETP (0.58) CETP
SCHEMBL6591032 0.91 CETP (0.57) CETP
SCHEMBL6591036 0.91 CETP (0.57) CETP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0987251-B1 4-carboxyamino-2-methyl-1,2,3,4-tetrahydroquinolines as CETP inhibitors PFIZER PROD INC (US) 2004-05-19 — — EP disclosed
US-6140342-A CHOLESTERYL ESTER TRANSFER PROTEIN INHIBITOR; USED TO ELEVATE CERTAIN PLASMA LIPID LEVELS, INCLUDING HIGH DENSITY LIPOPROTEIN-CHOLESTEROL AND TO LOWER CERTAIN OTHER PLASMA LIPID LEVELS, SUCH AS LDL-CHOLESTEROL AND TRIGLYCERIDES PFIZER INC. (US) 2000-10-31 — — US disclosed
EP-0987251-A1 4-carboxyamino-2-methyl-1,2,3,4-tetrahydroquinolines as CETP inhibitors Pfizer Products Inc. (US) 2000-03-22 — — EP disclosed