Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 14/20 | 0.66 |
| ▸ | CDK4 | P11802 | 5/20 | 0.66 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.51 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | SLC12A2 | P55011 | 1/20 | 0.48 |
| ▸ | SLC12A5 | Q9H2X9 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.47 |
| ▸ | CDK1 | P06493 | 1/20 | 0.47 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.47 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.47 |
| ▸ | CCND1 | P24385 | 1/20 | 0.47 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.47 |
| ▸ | CCND3 | P30281 | 1/20 | 0.47 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.47 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6387030 | 0.91 | CDK2 (0.60) | CDK2CDK4CCNA2CCNA1POLB | |
| SCHEMBL6598183 | 0.91 | CDK2 (0.64) | CDK2CDK4CCNA2CCNA1POLB | |
| SCHEMBL6106036 | 0.90 | CDK2 (0.64) | CDK2CDK4CCNA2CCNA1POLB | |
| SCHEMBL6103961 | 0.88 | CDK2 (0.72) | CDK2CDK4CCNA2CCNA1CCNT1 | |
| SCHEMBL5102624 | 0.86 | CDK2 (0.56) | CDK2CDK4CCNA2CCNA1POLB | |
| SCHEMBL6593911 | 0.85 | CDK2 (0.51) | CDK2CDK4CCNA2CCNA1POLB | |
| SCHEMBL4021384 | 0.85 | CDK2 (0.68) | CDK2CDK4CCNA2CCNA1CCNT1 | |
| SCHEMBL5095293 | 0.84 | CDK2 (0.59) | CDK2CDK4CCNA2CCNA1POLB | |
| SCHEMBL5095601 | 0.83 | CDK2 (0.54) | CDK2CDK4CCNA2CCNA1POLB | |
| SCHEMBL5098992 | 0.83 | CDK2 (0.60) | CDK2CDK4CCNA2CCNA1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1351958-B1 | IMIDAZOLO-5-YL-2-ANILINO-PYRIMIDINES AS AGENTS FOR THE INHIBITION OF THE CELL PROLIFERATION | ASTRAZENECA AB (SE) | 2004-06-16 | — | — | EP | disclosed |