SCHEMBL6594475

SCHEMBL6594475

CCOC(=O)N1c2cc(OC)ccc2C(N(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)C(=O)OC)CC1C

nearest known ligand 0.64

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
CETP P11597 20/20 0.64

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL992784 1.00 CETP (0.64) CETP
SCHEMBL6591448 0.93 CETP (0.71) CETP
SCHEMBL993013 0.93 CETP (0.71) CETP
SCHEMBL992791 0.92 CETP (0.72) CETP
SCHEMBL6393852 0.92 CETP (0.72) CETP
SCHEMBL992301 0.90 CETP (0.64) CETP
SCHEMBL6431243 0.90 CETP (0.64) CETP
SCHEMBL6592772 0.88 CETP (0.66) CETP
SCHEMBL1077543 0.88 CETP (0.73) CETP
SCHEMBL6587881 0.88 CETP (0.73) CETP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2258352-B1 PHARMACEUTICAL COMPOSITIONS OF CHOLESTERYL ESTER TRANSFER PROTEIN INHIBITORS BEND RES INC (US) 2015-05-13 EP disclosed
EP-0987251-B1 4-carboxyamino-2-methyl-1,2,3,4-tetrahydroquinolines as CETP inhibitors PFIZER PROD INC (US) 2004-05-19 EP disclosed
WO-2003000235-A9 PHARMACEUTICAL COMPOSITIONS OF DISPERSIONS OF DRUGS AND NEUTRAL POLYMERS PFIZER PROD INC (US) 2003-12-24 WO disclosed
US-6362198-B1 ANTICHOLESTEROL, ANTILIPEMIC AGENT PFIZER INC. 2002-03-26 US disclosed
EP-0987251-A1 4-carboxyamino-2-methyl-1,2,3,4-tetrahydroquinolines as CETP inhibitors Pfizer Products Inc. (US) 2000-03-22 EP disclosed