Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 4/20 | 0.79 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.46 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.44 |
| ▸ | HRH2 | P25021 | 1/20 | 0.42 |
| ▸ | HRH1 | P35367 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ILK | Q13418 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | RAF1 | P04049 | 1/20 | 0.39 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 2/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4503506 | 0.99 | CHEK1 (0.78) | CHEK1ALKIRAK4HRH2HRH1 | |
| SCHEMBL3940162 | 0.95 | CHEK1 (0.81) | CHEK1ALKIRAK4HRH2HRH1 | |
| SCHEMBL3939280 | 0.95 | CHEK1 (0.88) | CHEK1ALKHRH2HRH1HRH3 | |
| SCHEMBL7211233 | 0.88 | CHEK1 (1.00) | CHEK1ALKHRH2HRH1HRH3 | |
| Hydrochloric Acid SCHEMBL4497841 | 0.86 | CHEK1 (0.74) | CHEK1IRAK4HRH2HRH1HRH3 | |
| Hydrochloric Acid SCHEMBL4495599 | 0.86 | CHEK1 (0.74) | CHEK1IRAK4HRH2HRH1HRH3 | |
| SCHEMBL3935762 | 0.85 | CHEK1 (0.58) | CHEK1ALKIRAK4ILKMAP2K1 | |
| Hydrochloric Acid SCHEMBL4505074 | 0.83 | CHEK1 (0.63) | CHEK1ALKIRAK4PDGFRB | |
| SCHEMBL7205566 | 0.82 | CHEK1 (0.68) | CHEK1MAP2K1PDGFRB | |
| SCHEMBL3942219 | 0.82 | CHEK1 (0.60) | CHEK1ALKIRAK4ILKMAP2K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458394-A1 | USE OF OXINDOLE DERIVATIVES IN THE TREATMENT OF DEMENTIA RELATED DISEASES, ALZHEIMER S DISEASE AND CONDITIONS ASSOCIATED WITH GLYCOGEN SYNTHASE KINASE-3 | AstraZeneca AB (SE) | 2004-09-22 | — | — | EP | disclosed |
| WO-2003055492-A1 | USE OF OXINDOLE DERIVATIVES IN THE TREATMENT OF DEMENTIA RELATED DISEASES, ALZHEIMER'S DISEASE AND CONDITIONS ASSOCIATED WITH GLYCOGEN SYNTHASE KINASE-3 | ASTRAZENECA AB (SE) | 2003-07-10 | — | — | WO | disclosed |