Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 7/20 | 0.63 |
| ▸ | PDE4A | P27815 | 2/20 | 0.55 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.55 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.55 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.55 |
| ▸ | PDE2A | O00408 | 1/20 | 0.49 |
| ▸ | PDE1A | P54750 | 1/20 | 0.49 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.49 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | RHOA | P61586 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6592174 | 0.89 | PDE5A (0.58) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6593409 | 0.87 | PDE5A (0.63) | PDE5AMAPTALDH1A1KMT2APOLB | |
| SCHEMBL6594377 | 0.87 | PDE4A (0.72) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL146298 | 0.85 | PDE4A (0.76) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7904575 | 0.83 | PDE4A (0.72) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7914604 | 0.83 | PDE4A (0.57) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6598334 | 0.82 | PDE5A (0.84) | PDE5APDE2A | |
| SCHEMBL7918152 | 0.82 | PDE4A (0.57) | PDE5APDE4APDE4BPDE4CPDE4D | |
| Hydrochloric Acid SCHEMBL6596617 | 0.81 | PDE5A (0.84) | PDE5APDE2A | |
| SCHEMBL6598949 | 0.78 | PDE5A (0.67) | PDE5AMAPTKMT2APOLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6218392-B1 | FOR THERAPY AND PROPHYLAXIS OF ISCHEMIC HEART DISEASES SUCH AS ANGINA PECTORIS, MYOCARDIAL INFARCT AND CHRONIC AND ACUTE CARDIAC FAILURE, PULMONARY HYPERTENSION, ARTERIOSCLEROSIS AND BRONCHIAL ASTHMA | EISAI CO., LTD. (JP) | 2001-04-17 | — | — | US | claimed |
| EP-0722936-B1 | FUSED PYRIDAZINE COMPOUND | EISAI CO LTD (JP) | 2004-05-19 | — | — | EP | disclosed |
| US-6218392-B1 | FOR THERAPY AND PROPHYLAXIS OF ISCHEMIC HEART DISEASES SUCH AS ANGINA PECTORIS, MYOCARDIAL INFARCT AND CHRONIC AND ACUTE CARDIAC FAILURE, PULMONARY HYPERTENSION, ARTERIOSCLEROSIS AND BRONCHIAL ASTHMA | EISAI CO., LTD. (JP) | 2001-04-17 | — | — | US | disclosed |
| US-5849741-A | Fused pyridazine compounds | EISAI CO., LTD. (JP) | 1998-12-15 | — | — | US | disclosed |
| EP-0722936-A1 | FUSED PYRIDAZINE COMPOUND | Eisai Co., Ltd. (JP) | 1996-07-24 | — | — | EP | disclosed |