Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 1/20 | 0.47 |
| ▸ | CDK2 | P24941 | 1/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.47 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.45 |
| ▸ | PRKCG | P05129 | 1/20 | 0.45 |
| ▸ | PRKCB | P05771 | 1/20 | 0.45 |
| ▸ | PRKCA | P17252 | 1/20 | 0.45 |
| ▸ | PRKACA | P17612 | 1/20 | 0.45 |
| ▸ | PRKACG | P22612 | 1/20 | 0.45 |
| ▸ | PRKACB | P22694 | 1/20 | 0.45 |
| ▸ | PRKCH | P24723 | 1/20 | 0.45 |
| ▸ | PRKCI | P41743 | 1/20 | 0.45 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.45 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.45 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.45 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.45 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.45 |
| ▸ | BIRC5 | O15392 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | MKNK1 | Q9BUB5 | 4/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1840156 | 0.74 | CDC7 (0.49) | CDC7CDK2ROCK1PRKD3PRKCG | |
| SCHEMBL3148726 | 0.71 | POLB (0.56) | ROCK1MAPTMKNK1MKNK2ALDH1A1 | |
| SCHEMBL18797697 | 0.71 | MKNK1 (0.38) | CDK2MKNK1MKNK2MAPK8MAPK9 | |
| SCHEMBL27322596 | 0.69 | CDC7 (0.56) | CDC7CDK2ROCK1PRKD3PRKCG | |
| SCHEMBL13483673 | 0.69 | CDC7 (0.51) | CDC7CDK2ROCK1PRKD3PRKCG | |
| SCHEMBL31107087 | 0.69 | CDC7 (0.60) | CDC7CDK2ROCK1PRKD3PRKCG | |
| SCHEMBL524138 | 0.69 | CDC7 (0.60) | CDC7CDK2ROCK1PRKD3PRKCG | |
| SCHEMBL29388549 | 0.69 | CDC7 (0.60) | CDC7CDK2ROCK1PRKD3PRKCG | |
| SCHEMBL13052919 | 0.69 | BIRC5 (0.59) | CDC7CDK2ROCK1PRKD3PRKCG | |
| SCHEMBL2186020 | 0.68 | CDC7 (0.54) | CDC7CDK2ROCK1PRKD3PRKCG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1183252-B1 | PHARMACEUTICALLY ACTIVE COMPOUNDS | ASTRAZENECA AB (SE) | 2004-02-18 | — | — | EP | disclosed |
| CN-1053660-C | Process for preparing indole derivatives containing 1,2,4-triazol-1-yl substituents | MERCK SHARP & DOHME (GB) | 2000-06-21 | — | — | CN | disclosed |
| CN-1037843-C | Process for preparing indole derivatives containing 1,2, 4-triazol-1-yl substituents | MERCK SHARP & DOHME (GB) | 1998-03-25 | — | — | CN | disclosed |
| US-5717104-A | Process for preparing indole derivatives containing a 1,2,4-triazol-1-yl substituent | MERCK, SHARP & DOHME, LTD. (GB) | 1998-02-10 | — | — | US | disclosed |
| CN-1166486-A | Process for preparing indole derivatives containing 1,2,4-triazol-1-yl substituents | MERCK SHARP & DOHME (GB) | 1997-12-03 | — | — | CN | disclosed |
| EP-0651748-B1 | PROCESS FOR PREPARING INDOLE DERIVATIVES CONTAINING A 1,2,4-TRIAZOL-1-YL SUBSTITUENT | MERCK SHARP & DOHME (GB) | 1997-10-08 | — | — | EP | disclosed |
| US-5567819-A | Process for preparing indole derivatives containing a 1,2,4-triazol-1-yl substituent | MERCK, SHARP & DOHME, LTD. (GB) | 1996-10-22 | — | — | US | disclosed |
| EP-0651748-A1 | PROCESS FOR PREPARING INDOLE DERIVATIVES CONTAINING A 1,2,4-TRIAZOL-1-YL SUBSTITUENT. | MERCK SHARP & DOHME (GB) | 1995-05-10 | — | — | EP | disclosed |
| WO-1994002476-A1 | PROCESS FOR PREPARING INDOLE DERIVATIVES CONTAINING A 1,2,4-TRIAZOL-1-YL SUBSTITUENT | MERCK SHARP & DOHME LIMITED (GB) | 1994-02-03 | — | — | WO | disclosed |