Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 5/20 | 0.49 |
| ▸ | CETP | P11597 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.37 |
| ▸ | PRNP | P04156 | 1/20 | 0.37 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | APP | P05067 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6594651 | 1.00 | PTGDR2 (0.49) | PTGDR2CETPNPSR1PDE1CHTR2A | |
| SCHEMBL6594646 | 1.00 | PTGDR2 (0.49) | PTGDR2CETPNPSR1PDE1CHTR2A | |
| SCHEMBL6592187 | 0.97 | PTGDR2 (0.50) | PTGDR2CETPNPSR1PDE1CALDH1A1 | |
| SCHEMBL6592181 | 0.97 | PTGDR2 (0.50) | PTGDR2CETPNPSR1PDE1CALDH1A1 | |
| SCHEMBL6592191 | 0.97 | PTGDR2 (0.50) | PTGDR2CETPNPSR1PDE1CALDH1A1 | |
| SCHEMBL6588898 | 0.93 | CETP (0.49) | PTGDR2CETPNPSR1ALDH1A1LMNA | |
| SCHEMBL6588905 | 0.93 | CETP (0.49) | PTGDR2CETPNPSR1ALDH1A1LMNA | |
| SCHEMBL6588903 | 0.93 | CETP (0.49) | PTGDR2CETPNPSR1ALDH1A1LMNA | |
| SCHEMBL6596028 | 0.92 | PTGDR2 (0.45) | PTGDR2CETPNPSR1ALDH1A1LMNA | |
| SCHEMBL6596027 | 0.92 | PTGDR2 (0.45) | PTGDR2CETPNPSR1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0987251-B1 | 4-carboxyamino-2-methyl-1,2,3,4-tetrahydroquinolines as CETP inhibitors | PFIZER PROD INC (US) | 2004-05-19 | — | — | EP | disclosed |
| US-6362198-B1 | ANTICHOLESTEROL, ANTILIPEMIC AGENT | PFIZER INC. | 2002-03-26 | — | — | US | disclosed |
| US-6140342-A | CHOLESTERYL ESTER TRANSFER PROTEIN INHIBITOR; USED TO ELEVATE CERTAIN PLASMA LIPID LEVELS, INCLUDING HIGH DENSITY LIPOPROTEIN-CHOLESTEROL AND TO LOWER CERTAIN OTHER PLASMA LIPID LEVELS, SUCH AS LDL-CHOLESTEROL AND TRIGLYCERIDES | PFIZER INC. (US) | 2000-10-31 | — | — | US | disclosed |
| EP-0987251-A1 | 4-carboxyamino-2-methyl-1,2,3,4-tetrahydroquinolines as CETP inhibitors | Pfizer Products Inc. (US) | 2000-03-22 | — | — | EP | disclosed |