SCHEMBL6594871

SCHEMBL6594871

COc1cc(C(=O)N(C)CC(CCN2CCCN(c3nc4ccccc4[nH]3)CC2)c2ccccc2)cc(OC)c1OC

nearest known ligand 0.49

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
TACR2 P21452 11/20 0.49
KCNH2 Q12809 1/20 0.42
TACR1 P25103 1/20 0.40
TP53 P04637 1/20 0.39
USP2 O75604 1/20 0.39
LMNA P02545 1/20 0.39
POLB P06746 1/20 0.39
HRH1 P35367 1/20 0.39
SLC29A1 Q99808 1/20 0.39
HTR1A P08908 1/20 0.38
HTR1D P28221 1/20 0.38
HTR2B P41595 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6599761 0.95 TACR2 (0.47) TACR2KCNH2TACR1TP53USP2
SCHEMBL6596626 0.95 TACR2 (0.46) TACR2KCNH2TACR1TP53USP2
SCHEMBL6593670 0.94 TACR2 (0.47) TACR2KCNH2TACR1TP53USP2
SCHEMBL6595423 0.94 TACR2 (0.50) TACR2KCNH2TACR1
SCHEMBL6604253 0.94 TACR2 (0.46) TACR2KCNH2TACR1TP53USP2
SCHEMBL6597372 0.94 TACR2 (0.49) TACR2KCNH2TACR1TP53USP2
SCHEMBL6594547 0.93 TACR2 (0.49) TACR2KCNH2TACR1LMNA
SCHEMBL6597581 0.93 TACR2 (0.44) TACR2KCNH2TACR1TP53USP2
SCHEMBL6598755 0.93 TACR2 (0.45) TACR2KCNH2TACR1TP53LMNA
SCHEMBL6597452 0.92 TACR2 (0.48) TACR2KCNH2TACR1TP53USP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0888338-B1 NOVEL SUBSTITUTED N-METHYL-N-(4-(4-(1H-BENZIMIDAZOL-2-YL) 1,4]DIAZEPAN-1-YL)-2-(ARYL)BUTYL)BENZAMIDES USEFUL FOR THE TREATMENT OF ALLERGIC DISEASES AVENTIS PHARMA INC (US) 2004-11-17 EP disclosed
EP-0888338-A1 NOVEL SUBSTITUTED N-METHYL-N-(4-(4-(1H-BENZIMIDAZOL-2-YL) 1,4]DIAZEPAN-1-YL)-2-(ARYL)BUTYL)BENZAMIDES USEFUL FOR THE TREATMENT OF ALLERGIC DISEASES HOECHST MARION ROUSSEL, INC. (US) 1999-01-07 EP disclosed
WO-1997030991-A1 NOVEL SUBSTITUTED N-METHYL-N-(4-(4-(1H-BENZIMIDAZOL-2-YL)[1,4]DIAZEPAN-1-YL)-2-(ARYL)BUTYL)BENZAMIDES USEFUL FOR THE TREATMENT OF ALLERGIC DISEASES HOECHST MARION ROUSSEL, INC. (US) 1997-08-28 WO disclosed