Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.58 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | MAOB | P27338 | 9/20 | 0.46 |
| ▸ | P4HB | P07237 | 1/20 | 0.46 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.46 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | BACE1 | P56817 | 1/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.42 |
| ▸ | APP | P05067 | 1/20 | 0.41 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.40 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.40 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.40 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.40 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.40 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6595029 | 1.00 | TNF (0.58) | TNFRAB9ANOD1NFKB1MAOB | |
| SCHEMBL6593793 | 0.83 | TNF (0.48) | TNFRAB9ANOD1NFKB1MAOB | |
| SCHEMBL6593788 | 0.83 | TNF (0.48) | TNFRAB9ANOD1NFKB1MAOB | |
| SCHEMBL6591632 | 0.74 | TNF (1.00) | TNFRAB9ANOD1NFKB1MAOB | |
| SCHEMBL28157024 | 0.74 | KMT2A (0.65) | RAB9AMEN1LMNAMAPTKMT2A | |
| SCHEMBL6597650 | 0.74 | TNF (0.76) | TNFRAB9ANOD1NFKB1MAOB | |
| SCHEMBL6597657 | 0.74 | TNF (0.76) | TNFRAB9ANOD1NFKB1MAOB | |
| SCHEMBL6591636 | 0.74 | TNF (1.00) | TNFRAB9ANOD1NFKB1MAOB | |
| SCHEMBL6591446 | 0.71 | TNF (0.83) | TNFRAB9ANOD1NFKB1MAOB | |
| SCHEMBL6592328 | 0.71 | TNF (0.71) | TNFRAB9ANOD1NFKB1MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004016271-A1 | PYRIMIDONES AS ANTIVIRAL AGENTS | AXXIMA PHARMACEUTICALS AG (DE) | 2004-02-26 | — | — | WO | claimed |
| EP-1389461-A1 | Pyrimidones with antiviral properties | Axxima Pharmaceuticals Aktiengesellschaft (DE) | 2004-02-18 | — | — | EP | claimed |
| WO-2004016271-A1 | PYRIMIDONES AS ANTIVIRAL AGENTS | AXXIMA PHARMACEUTICALS AG (DE) | 2004-02-26 | — | — | WO | disclosed |
| EP-1389461-A1 | Pyrimidones with antiviral properties | Axxima Pharmaceuticals Aktiengesellschaft (DE) | 2004-02-18 | — | — | EP | disclosed |