Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 16/20 | 0.67 |
| ▸ | PARP2 | Q9UGN5 | 4/20 | 0.67 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.52 |
| ▸ | AURKA | O14965 | 2/20 | 0.52 |
| ▸ | PIM1 | P11309 | 2/20 | 0.51 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.51 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.51 |
| ▸ | FLT3 | P36888 | 1/20 | 0.51 |
| ▸ | BRSK1 | Q8TDC3 | 1/20 | 0.51 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.50 |
| ▸ | SRC | P12931 | 1/20 | 0.50 |
| ▸ | FLT4 | P35916 | 1/20 | 0.50 |
| ▸ | KDR | P35968 | 1/20 | 0.50 |
| ▸ | CLK2 | P49760 | 1/20 | 0.50 |
| ▸ | GSK3A | P49840 | 1/20 | 0.50 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.50 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.50 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.50 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL655588 | 0.90 | PARP1 (0.66) | PARP1PARP2AURKBPIM1PIM3 | |
| SCHEMBL659642 | 0.85 | PARP1 (0.68) | PARP1PARP2 | |
| SCHEMBL659428 | 0.84 | PARP1 (0.63) | PARP1PARP2 | |
| SCHEMBL658210 | 0.83 | PARP1 (0.64) | PARP1PARP2AURKBPIM1PIM3 | |
| SCHEMBL423949 | 0.81 | PARP1 (1.00) | PARP1PARP2 | |
| SCHEMBL4967855 | 0.79 | PARP1 (0.79) | PARP1PARP2AURKBAURKA | |
| SCHEMBL630104 | 0.78 | PARP1 (1.00) | PARP1PARP2 | |
| Succinic Acid SCHEMBL29396818 | 0.77 | PARP1 (0.90) | PARP1PARP2 | |
| SCHEMBL5621649 | 0.74 | PARP1 (0.86) | PARP1PARP2 | |
| Hydrochloric Acid SCHEMBL5620758 | 0.74 | PARP1 (0.86) | PARP1PARP2AURKBAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8067613-B2 | Benzimidazole poly(ADP ribose)polymerase inhibitors | ABBOTT LABORATORIES (US) | 2011-11-29 | — | — | US | claimed |
| US-20090030016-A1 | BENZIMIDAZOLE POLY(ADP RIBOSE)POLYMERASE INHIBITORS | ABBOTT LABORATORIES (US) | 2009-01-29 | — | — | US | claimed |
| US-20120046303-A1 | BENZIMIDAZOLE POLY(ADP RIBOSE)POLYMERASE INHIBITORS | ABBOTT LABORATORIES (US) | 2012-02-23 | — | — | US | disclosed |
| US-8067613-B2 | Benzimidazole poly(ADP ribose)polymerase inhibitors | ABBOTT LABORATORIES (US) | 2011-11-29 | — | — | US | disclosed |
| US-20090030016-A1 | BENZIMIDAZOLE POLY(ADP RIBOSE)POLYMERASE INHIBITORS | ABBOTT LABORATORIES (US) | 2009-01-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090030016-A1 | BENZIMIDAZOLE POLY(ADP RIBOSE)POLYMERASE INHIBITORS | PARP1, PARP2, PARP3 | PARP1 1/4885PARP2 2/4885AURKB 546/4885 |
| US-20120046303-A1 | BENZIMIDAZOLE POLY(ADP RIBOSE)POLYMERASE INHIBITORS | PARP1, PARP2, PARP3 | PARP1 1/4885PARP2 2/4885AURKB 546/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.