Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.64 |
| ▸ | CA1 | P00915 | 5/20 | 0.64 |
| ▸ | CA2 | P00918 | 5/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.61 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | MMP1 | P03956 | 1/20 | 0.46 |
| ▸ | MMP2 | P08253 | 1/20 | 0.46 |
| ▸ | MMP9 | P14780 | 1/20 | 0.46 |
| ▸ | MMP8 | P22894 | 1/20 | 0.46 |
| ▸ | MMP13 | P45452 | 1/20 | 0.46 |
| ▸ | GBA1 | P04062 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5599840 | 0.85 | MEN1 (0.66) | MEN1KMT2ACA2ALDH1A1GBA1 | |
| SCHEMBL17255140 | 0.83 | KMT2A (0.63) | MEN1KMT2AALDH1A1PKMGBA1 | |
| SCHEMBL3133953 | 0.81 | CA1 (0.75) | CA1CA2ALDH1A1SIGMAR1MMP1 | |
| SCHEMBL19392455 | 0.81 | MEN1 (0.61) | MEN1KMT2ACA2ALDH1A1PKM | |
| SCHEMBL29960153 | 0.80 | MEN1 (0.59) | MEN1KMT2ACA1CA2ALDH1A1 | |
| SCHEMBL27606322 | 0.79 | CA1 (0.55) | MEN1KMT2ACA1CA2ALDH1A1 | |
| SCHEMBL6320964 | 0.78 | CA1 (0.71) | CA1CA2ALDH1A1SIGMAR1MMP1 | |
| Formamide SCHEMBL28154904 | 0.76 | KMT2A (0.56) | MEN1KMT2AALDH1A1PKMGBA1 | |
| SCHEMBL15482079 | 0.76 | MEN1 (0.56) | MEN1KMT2ACA1CA2ALDH1A1 | |
| SCHEMBL6595788 | 0.75 | MAPK1 (0.71) | MEN1KMT2ACA1CA2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1351958-B1 | IMIDAZOLO-5-YL-2-ANILINO-PYRIMIDINES AS AGENTS FOR THE INHIBITION OF THE CELL PROLIFERATION | ASTRAZENECA AB (SE) | 2004-06-16 | — | — | EP | disclosed |