Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 17/20 | 0.77 |
| ▸ | CDK4 | P11802 | 6/20 | 0.77 |
| ▸ | IKBKB | O14920 | 3/20 | 0.56 |
| ▸ | CDK1 | P06493 | 3/20 | 0.56 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.52 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.52 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.52 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.52 |
| ▸ | CCND1 | P24385 | 1/20 | 0.52 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.52 |
| ▸ | CCND3 | P30281 | 1/20 | 0.52 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.52 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.52 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.52 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.52 |
| ▸ | GSK3A | P49840 | 1/20 | 0.52 |
| ▸ | GSK3B | P49841 | 1/20 | 0.52 |
| ▸ | CDK7 | P50613 | 1/20 | 0.52 |
| ▸ | CDK9 | P50750 | 1/20 | 0.52 |
| ▸ | CCNH | P51946 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6592484 | 0.96 | CDK2 (0.74) | CDK2CDK4IKBKBCDK1CCNT1 | |
| SCHEMBL6595834 | 0.95 | CDK2 (0.81) | CDK2CDK4IKBKBCDK1CCNT1 | |
| SCHEMBL6596882 | 0.91 | CDK2 (0.77) | CDK2CDK4IKBKBCDK1CCNT1 | |
| SCHEMBL6596936 | 0.89 | CDK2 (0.81) | CDK2CDK4IKBKBCDK1CCNT1 | |
| SCHEMBL6596141 | 0.89 | CDK2 (0.80) | CDK2CDK4IKBKBCDK1 | |
| SCHEMBL6593918 | 0.89 | CDK2 (0.90) | CDK2CDK4CDK1CCNT1CCNB1 | |
| SCHEMBL6104547 | 0.88 | CDK2 (0.78) | CDK2CDK4IKBKBCDK1CCNT1 | |
| SCHEMBL6595482 | 0.87 | CDK2 (0.80) | CDK2CDK4CDK1CCNT1CCNB1 | |
| SCHEMBL6595783 | 0.87 | CDK2 (0.77) | CDK2CDK4CDK1CCNT1CCNB1 | |
| SCHEMBL27533826 | 0.87 | CDK2 (0.71) | CDK2CDK4IKBKBCDK1CCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1269813-C | Imidazolo-5-yl-2-anilino-pyrimidines as agents for inhibition of cell proliferation | ASTRAZENECA AB (SE) | 2006-08-16 | — | — | CN | disclosed |
| EP-1351958-B1 | IMIDAZOLO-5-YL-2-ANILINO-PYRIMIDINES AS AGENTS FOR THE INHIBITION OF THE CELL PROLIFERATION | ASTRAZENECA AB (SE) | 2004-06-16 | — | — | EP | disclosed |