SCHEMBL659571

SCHEMBL659571

NC(=O)c1cccc2c1ccc1ccccc12

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 5/20 0.59
ALDH1A1 P00352 3/20 0.59
GAA P10253 2/20 0.59
POLB P06746 1/20 0.54
SMN1; SMN2 Q16637 1/20 0.54
HPRT1 P00492 2/20 0.54
NR4A1 P22736 1/20 0.52
NR4A2 P43354 1/20 0.52
NR4A3 Q92570 1/20 0.52
KMT2A Q03164 2/20 0.52
ATM Q13315 1/20 0.52
MEN1 O00255 1/20 0.50
MMP3 P08254 1/20 0.47
HDAC8 Q9BY41 1/20 0.47
PARP1 P09874 2/20 0.46
TSHR P16473 2/20 0.46
HSD17B10 Q99714 2/20 0.46
CYP2A6 P11509 1/20 0.46
TDP1 Q9NUW8 1/20 0.46
HTT P42858 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27902907 1.00 KDM4E (0.59) KDM4EALDH1A1GAAPOLBSMN1; SMN2
SCHEMBL30415690 1.00 KDM4E (0.59) KDM4EALDH1A1GAAPOLBSMN1; SMN2
Hydrochloric Acid SCHEMBL30561222 0.98 KDM4E (0.58) KDM4EALDH1A1GAAPOLBSMN1; SMN2
SCHEMBL43084 0.88 KDM4E (0.68) KDM4EALDH1A1GAAPOLBSMN1; SMN2
SCHEMBL29381201 0.88 KDM4E (0.68) KDM4EALDH1A1GAAPOLBSMN1; SMN2
Hydrochloric Acid SCHEMBL3149083 0.86 KDM4E (0.66) KDM4EALDH1A1GAAPOLBSMN1; SMN2
SCHEMBL18859030 0.86 KDM4E (0.66) KDM4EALDH1A1GAAPOLBSMN1; SMN2
SCHEMBL18859029 0.86 KDM4E (0.66) KDM4EALDH1A1GAAPOLBSMN1; SMN2
SCHEMBL9011545 0.86 KDM4E (0.66) KDM4EALDH1A1GAAPOLBSMN1; SMN2
Ammonia Solution, Strong SCHEMBL1553414 0.86 KDM4E (0.66) KDM4EALDH1A1GAAPOLBSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 114 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118772223-A Compositions and methods for treating central nervous system disorders 萨奇治疗股份有限公司 2024-10-15 CN disclosed
CN-111741965-B Compositions and methods for treating central nervous system disorders 萨奇治疗股份有限公司 2024-06-25 CN disclosed
WO-2024128000-A1 ISOPOLYOXOTUNGSTATE SALT COMPOUND, SOLVATE THEREOF OR MIXTURE OF SAID COMPOUND AND SOLVATE, AND METHOD FOR PRODUCING SAID COMPOUND, SOLVATE OR MIXTURE 東京応化工業株式会社 2024-06-20 WO disclosed
CN-116813979-A Nucleating agent, synthetic resin composition containing same, and molded article thereof 株式会社ADEKA 2023-09-29 CN disclosed
CN-110740991-B Novel biphenyl compound or salt thereof 大鹏药品工业株式会社 2023-07-04 CN disclosed
EP-3632443-B1 ANTI-TUMOR EFFECT POTENTIATOR USING A BIPHENYL COMPOUND TAIHO PHARMACEUTICAL CO LTD (JP) 2023-06-07 EP disclosed
CN-112839988-B Nucleating agent, synthetic resin composition containing same, and molded article thereof 株式会社ADEKA 2023-06-06 CN disclosed
CN-112672816-B Aromatic amide dispersants 路博润先进材料公司 2023-01-20 CN disclosed
EP-3381896-B1 BIPHENYL COMPOUND OR SALT THEREOF TAIHO PHARMACEUTICAL CO LTD (JP) 2023-01-18 EP disclosed
CN-108602770-B Novel biphenyl compound or salt thereof 大鹏药品工业株式会社 2022-02-08 CN disclosed
WO-2004052363-A1 OXAZOLIDINONES USED AS ANTIVIRAL AGENTS, IN PARTICULAR FOR FIGHTING AGAINST CYTOMEGALOVIRUS BAYER HEALTHCARE AG (DE) 2004-06-24 WO disclosed
WO-2004037776-A2 NOVEL COMPOUNDS AND THEIR USE AS PRAR-MODULATORS NOVO NORDISK A/S (DK) 2004-05-06 WO disclosed
WO-2004037775-A1 NOVEL COMPOUNDS USEFUL IN TREATING PPAR MEDIATED DISEASES NOVO NORDISK A/S (DK) 2004-05-06 WO disclosed
WO-2004022533-A1 NOVEL VINYL CARBOXYLIC ACID DERIVATIVES AND THEIR THERAPEUTICAL USE NOVO NORDISK A/S (DK) 2004-03-18 WO disclosed
WO-2004020432-A1 ARYLAMIDES BAYER HEALTHCARE AG (DE) 2004-03-11 WO disclosed
EP-0765879-B1 13-Substituted milbemycin 5-oxime derivatives, their preparation and their use against insects and other pests SANKYO CO (JP) 2001-02-14 EP disclosed
US-6005116-A HAVE INHIBITION ACTIVITIES AGAINST TYPE A-MONOAMINE OXIDASE; TREATING OR PREVENTING DEPRESSION, PARKINSON'S DISEASE, ALZEHEIMER'S DEMENTIA, OR CEREBROVASCULAR DEMENTIA SANKYO COMPANY, LIMITED (JP) 1999-12-21 US disclosed
US-5861429-A MITICIDES AND ANTHELMINTICS SANKYO COMPANY, LIMITED (JP) 1999-01-19 US disclosed
EP-0885891-A1 ISOXAZOLE DERIVATIVES SANKYO COMPANY LIMITED (JP) 1998-12-23 EP disclosed
EP-0765879-A1 13-Substituted milbemycin 5-oxime derivatives, their preparation and their use against insects and other pests SANKYO COMPANY LIMITED (JP) 1997-04-02 EP disclosed