SCHEMBL6596243

SCHEMBL6596243

COc1ccc(C2C=NN=N2)cc1C(=O)N(C)CC(CCN1CCCN(c2nc3ccccc3n2Cc2ccco2)CC1)c1ccc(F)cc1

nearest known ligand 0.35

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
MAPT P10636 2/20 0.34
MEN1 O00255 1/20 0.34
ALDH1A1 P00352 1/20 0.34
GAA P10253 1/20 0.34
HTT P42858 1/20 0.34
KMT2A Q03164 1/20 0.34
HRH1 P35367 10/20 0.34
CYP2D6 P10635 7/20 0.34
CHRM1 P11229 4/20 0.34
KCNH2 Q12809 4/20 0.33
TACR2 P21452 2/20 0.32
TSHR P16473 1/20 0.32
DRD2 P14416 1/20 0.32
DRD4 P21917 1/20 0.32
DRD3 P35462 1/20 0.32
ADRA2A P08913 1/20 0.31
HTR2B P41595 1/20 0.31
PDE4D Q08499 1/20 0.31
PDE3A Q14432 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6596598 0.93 TACR2 (0.41) TACR2
SCHEMBL6592535 0.91 HRH1 (0.36) HRH1CYP2D6CHRM1KCNH2ADRA2A
SCHEMBL6594882 0.90 SMN1; SMN2 (0.37) ALDH1A1TSHRDRD2DRD4DRD3
SCHEMBL6593625 0.90 CHRM1 (0.39) HRH1CHRM1KCNH2
SCHEMBL6596980 0.90 TACR2 (0.33) MEN1KMT2AHRH1CYP2D6CHRM1
SCHEMBL6597750 0.89 MEN1 (0.35) MEN1KMT2AHRH1CYP2D6CHRM1
SCHEMBL6598850 0.89 TACR2 (0.33) HRH1CYP2D6CHRM1KCNH2TACR2
SCHEMBL6596349 0.89 TACR2 (0.33) MAPTMEN1ALDH1A1KMT2AHRH1
SCHEMBL6596344 0.89 TACR2 (0.33) MAPTMEN1ALDH1A1KMT2AHRH1
SCHEMBL7494638 0.88 KCNH2 (0.41) MAPTMEN1ALDH1A1GAAHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0888338-B1 NOVEL SUBSTITUTED N-METHYL-N-(4-(4-(1H-BENZIMIDAZOL-2-YL) 1,4]DIAZEPAN-1-YL)-2-(ARYL)BUTYL)BENZAMIDES USEFUL FOR THE TREATMENT OF ALLERGIC DISEASES AVENTIS PHARMA INC (US) 2004-11-17 EP disclosed
EP-0888338-A1 NOVEL SUBSTITUTED N-METHYL-N-(4-(4-(1H-BENZIMIDAZOL-2-YL) 1,4]DIAZEPAN-1-YL)-2-(ARYL)BUTYL)BENZAMIDES USEFUL FOR THE TREATMENT OF ALLERGIC DISEASES HOECHST MARION ROUSSEL, INC. (US) 1999-01-07 EP disclosed
WO-1997030991-A1 NOVEL SUBSTITUTED N-METHYL-N-(4-(4-(1H-BENZIMIDAZOL-2-YL)[1,4]DIAZEPAN-1-YL)-2-(ARYL)BUTYL)BENZAMIDES USEFUL FOR THE TREATMENT OF ALLERGIC DISEASES HOECHST MARION ROUSSEL, INC. (US) 1997-08-28 WO disclosed