Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 7/20 | 0.42 |
| ▸ | TACR2 | P21452 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6594153 | 0.95 | HRH1 (0.45) | HRH1TACR2MAPTMEN1ALDH1A1 | |
| SCHEMBL6595781 | 0.94 | HRH1 (0.42) | HRH1TACR2MAPTALDH1A1CYP2D6 | |
| SCHEMBL6595631 | 0.94 | HRH1 (0.41) | HRH1TACR2MAPTMEN1ALDH1A1 | |
| SCHEMBL6596435 | 0.94 | HRH1 (0.43) | HRH1TACR2MAPTMEN1GAA | |
| SCHEMBL6598213 | 0.93 | HRH1 (0.41) | HRH1TACR2MAPTMEN1ALDH1A1 | |
| SCHEMBL6597240 | 0.93 | HRH1 (0.42) | HRH1TACR2MAPTMEN1ALDH1A1 | |
| SCHEMBL6596376 | 0.93 | HRH1 (0.42) | HRH1TACR2MAPTALDH1A1 | |
| SCHEMBL6596996 | 0.92 | HRH1 (0.45) | HRH1TACR2 | |
| SCHEMBL6596218 | 0.92 | HRH1 (0.42) | HRH1TACR2MAPTMEN1ALDH1A1 | |
| SCHEMBL6594052 | 0.92 | TACR2 (0.49) | HRH1TACR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888338-B1 | NOVEL SUBSTITUTED N-METHYL-N-(4-(4-(1H-BENZIMIDAZOL-2-YL) 1,4]DIAZEPAN-1-YL)-2-(ARYL)BUTYL)BENZAMIDES USEFUL FOR THE TREATMENT OF ALLERGIC DISEASES | AVENTIS PHARMA INC (US) | 2004-11-17 | — | — | EP | disclosed |
| EP-0888338-A1 | NOVEL SUBSTITUTED N-METHYL-N-(4-(4-(1H-BENZIMIDAZOL-2-YL) 1,4]DIAZEPAN-1-YL)-2-(ARYL)BUTYL)BENZAMIDES USEFUL FOR THE TREATMENT OF ALLERGIC DISEASES | HOECHST MARION ROUSSEL, INC. (US) | 1999-01-07 | — | — | EP | disclosed |
| WO-1997030991-A1 | NOVEL SUBSTITUTED N-METHYL-N-(4-(4-(1H-BENZIMIDAZOL-2-YL)[1,4]DIAZEPAN-1-YL)-2-(ARYL)BUTYL)BENZAMIDES USEFUL FOR THE TREATMENT OF ALLERGIC DISEASES | HOECHST MARION ROUSSEL, INC. (US) | 1997-08-28 | — | — | WO | disclosed |