Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 8/20 | 0.64 |
| ▸ | CDK4 | P11802 | 4/20 | 0.64 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.64 |
| ▸ | KDR | P35968 | 8/20 | 0.63 |
| ▸ | PTK2 | Q05397 | 7/20 | 0.63 |
| ▸ | PLK1 | P53350 | 4/20 | 0.63 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.52 |
| ▸ | AKT1 | P31749 | 2/20 | 0.52 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.50 |
| ▸ | ABL1 | P00519 | 1/20 | 0.50 |
| ▸ | EGFR | P00533 | 1/20 | 0.50 |
| ▸ | PRKCA | P17252 | 1/20 | 0.50 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.48 |
| ▸ | IKBKB | O14920 | 1/20 | 0.48 |
| ▸ | AURKA | O14965 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.48 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.48 |
| ▸ | PRKCG | P05129 | 1/20 | 0.48 |
| ▸ | CDK1 | P06493 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4819158 | 0.83 | CDK2 (0.60) | CDK2CDK4CCNE1KDRPTK2 | |
| SCHEMBL6593928 | 0.82 | CDK2 (0.69) | CDK2CDK4IKBKBCDK1JAK2 | |
| SCHEMBL6596039 | 0.81 | CDK2 (0.72) | CDK2CDK4CCNE1KDRPTK2 | |
| SCHEMBL5105343 | 0.78 | CDK2 (0.69) | CDK2CDK4CCNE1KDRPTK2 | |
| SCHEMBL6593019 | 0.78 | CDK2 (0.68) | CDK2CDK4CCNE1KDRPTK2 | |
| SCHEMBL6245628 | 0.77 | CDK2 (0.69) | CDK2CDK4CCNE1KDRPTK2 | |
| SCHEMBL6598042 | 0.77 | CDK2 (0.66) | CDK2CDK4CCNE1PLK1IKBKB | |
| SCHEMBL4826063 | 0.76 | CDK2 (0.58) | CDK2CDK4CCNE1KDRPTK2 | |
| Dimethylamine SCHEMBL6593494 | 0.75 | CDK2 (0.78) | CDK2CDK4IKBKBCDK1 | |
| SCHEMBL1593016 | 0.73 | PRKCD (0.79) | CDK2CDK4PLK1PRKCDABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1269813-C | Imidazolo-5-yl-2-anilino-pyrimidines as agents for inhibition of cell proliferation | ASTRAZENECA AB (SE) | 2006-08-16 | — | — | CN | disclosed |
| EP-1351958-B1 | IMIDAZOLO-5-YL-2-ANILINO-PYRIMIDINES AS AGENTS FOR THE INHIBITION OF THE CELL PROLIFERATION | ASTRAZENECA AB (SE) | 2004-06-16 | — | — | EP | disclosed |