Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Pyruvate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | THPO | P40225 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | FFAR3 | O14843 | 3/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
| ▸ | FYN | P06241 | 1/20 | 0.33 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.32 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.31 |
| ▸ | CES1 | P23141 | 1/20 | 0.31 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.30 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.30 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.30 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.30 |
| ▸ | EP300 | Q09472 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.30 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pyruvate SCHEMBL27831035 | 1.00 | TSHR (0.41) | TSHRTHPOALDH1A1FFAR3TDP1 | |
| Acetic Acid SCHEMBL10531259 | 0.88 | FFAR3 (0.47) | TSHRTHPOALDH1A1FFAR3TDP1 | |
| Pyruvate SCHEMBL2404785 | 0.87 | — | — | |
| Pyruvate SCHEMBL27849498 | 0.87 | — | — | |
| Acetic Acid SCHEMBL11302189 | 0.85 | FFAR3 (0.44) | TSHRTHPOALDH1A1FFAR3TDP1 | |
| Pyruvate SCHEMBL9721321 | 0.84 | FFAR3 (0.50) | TSHRTHPOALDH1A1FFAR3LCK | |
| Pyruvate SCHEMBL27732740 | 0.84 | TSHR (0.50) | TSHRTHPOALDH1A1FFAR3TDP1 | |
| Acetic Acid SCHEMBL7868070 | 0.82 | FFAR3 (0.41) | TSHRTHPOALDH1A1FFAR3TDP1 | |
| Pyruvate SCHEMBL9721331 | 0.81 | TSHR (0.40) | TSHRTHPOALDH1A1FFAR3LCK | |
| Acetaldehyde SCHEMBL3400941 | 0.80 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120045821-A1 | METHODS AND COMPOSITIONS FOR GENETIC ENGINEERING OF CYANOBACTERIA TO PRODUCE ETHANOL | HELIO BIOTECHNOLOGY CORPORATION | 2012-02-23 | — | — | US | disclosed |
| CN-101372669-B | Cyanobacteria modified by gene engineering and use thereof for producing ethanol | Xulier Biotechnology Co., Ltd. (US) | 2011-12-28 | — | — | CN | disclosed |
| CN-101372669-A | Cyanobacteria modified by gene engineering and use thereof for producing ethanol | JUAN HUANG (AU) | 2009-02-25 | — | — | CN | disclosed |