Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE1C | Q14123 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.41 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.41 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.41 |
| ▸ | PRNP | P04156 | 1/20 | 0.41 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6594251 | 0.91 | NPC1 (0.43) | PDE1CKDM4ESMN1; SMN2ALDH1A1PDE4B | |
| SCHEMBL5778168 | 0.85 | KDM4E (0.52) | HTR2CKDM4ETSHRMCL1ALDH1A1 | |
| SCHEMBL6596289 | 0.85 | HTR2C (0.42) | PDE1CHTR2CPTGDR2TSHRMCL1 | |
| SCHEMBL6596287 | 0.85 | HTR2C (0.42) | PDE1CHTR2CPTGDR2TSHRMCL1 | |
| SCHEMBL31736935 | 0.84 | PTGDR2 (0.52) | HTR2CPTGDR2CACNA1GCACNA1HCACNA1I | |
| SCHEMBL4114235 | 0.84 | PTGDR2 (0.52) | HTR2CPTGDR2CACNA1GCACNA1HCACNA1I | |
| SCHEMBL11713252 | 0.81 | TSHR (0.44) | KDM4ETSHRMCL1ALDH1A1KMT2A | |
| SCHEMBL11709337 | 0.81 | KMT2A (0.43) | HTR2CKDM4ETSHRMCL1SMN1; SMN2 | |
| SCHEMBL6589400 | 0.81 | HTR2C (0.42) | HTR2CPTGDR2CACNA1GCACNA1HCACNA1I | |
| SCHEMBL6588563 | 0.80 | GPBAR1 (0.45) | HTR2CPTGDR2TSHRCACNA1GCACNA1H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0987251-B1 | 4-carboxyamino-2-methyl-1,2,3,4-tetrahydroquinolines as CETP inhibitors | PFIZER PROD INC (US) | 2004-05-19 | — | — | EP | disclosed |
| US-6362198-B1 | ANTICHOLESTEROL, ANTILIPEMIC AGENT | PFIZER INC. | 2002-03-26 | — | — | US | disclosed |
| US-6140342-A | CHOLESTERYL ESTER TRANSFER PROTEIN INHIBITOR; USED TO ELEVATE CERTAIN PLASMA LIPID LEVELS, INCLUDING HIGH DENSITY LIPOPROTEIN-CHOLESTEROL AND TO LOWER CERTAIN OTHER PLASMA LIPID LEVELS, SUCH AS LDL-CHOLESTEROL AND TRIGLYCERIDES | PFIZER INC. (US) | 2000-10-31 | — | — | US | disclosed |
| EP-0987251-A1 | 4-carboxyamino-2-methyl-1,2,3,4-tetrahydroquinolines as CETP inhibitors | Pfizer Products Inc. (US) | 2000-03-22 | — | — | EP | disclosed |
| US-4018758-A | ANALGESICS | PFIZER INC. (US) | 1977-04-19 | — | — | US | disclosed |
| US-4013662-A | ANALGESICS, TRANQUILIZERS | PFIZER INC. (US) | 1977-03-22 | — | — | US | disclosed |
| US-3978064-A | ANALGESIC | PFIZER INC. (US) | 1976-08-31 | — | — | US | disclosed |
| US-3976650-A | Process for preparing optically active 6,7-dimethoxy-2-methyl-4-oxo-1,2,3,4-tetrahydro-1-quinoline carboxylic acid ester analgesics | PFIZER INC. (US) | 1976-08-24 | — | — | US | disclosed |