Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 15/20 | 0.73 |
| ▸ | CCNE2 | O96020 | 13/20 | 0.73 |
| ▸ | CCNE1 | P24864 | 13/20 | 0.73 |
| ▸ | CDK2 | P24941 | 13/20 | 0.73 |
| ▸ | GSK3A | P49840 | 1/20 | 0.66 |
| ▸ | ATR | Q13535 | 5/20 | 0.62 |
| ▸ | ATRIP | Q8WXE1 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6034611 | 0.99 | GSK3B (0.72) | GSK3BCCNE2CCNE1CDK2GSK3A | |
| SCHEMBL6034231 | 0.95 | GSK3B (0.71) | GSK3BCCNE2CCNE1CDK2GSK3A | |
| Hydrochloric Acid SCHEMBL6035843 | 0.88 | GSK3B (0.71) | GSK3BCCNE2CCNE1CDK2GSK3A | |
| SCHEMBL6034766 | 0.88 | GSK3B (0.71) | GSK3BCCNE2CCNE1CDK2GSK3A | |
| SCHEMBL6034644 | 0.86 | ATR (0.84) | GSK3BCCNE2CCNE1CDK2GSK3A | |
| Hydrochloric Acid SCHEMBL6035259 | 0.85 | GSK3B (0.66) | GSK3BCCNE2CCNE1CDK2GSK3A | |
| SCHEMBL6034152 | 0.85 | ATR (0.84) | GSK3BCCNE2CCNE1CDK2GSK3A | |
| Hydrochloric Acid SCHEMBL3149256 | 0.85 | ATR (0.82) | GSK3BCCNE2CCNE1CDK2GSK3A | |
| SCHEMBL31061310 | 0.85 | GSK3B (1.00) | GSK3BCCNE2CCNE1CDK2GSK3A | |
| SCHEMBL31259907 | 0.85 | GSK3B (1.00) | GSK3BCCNE2CCNE1CDK2GSK3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1414801-A1 | ARYLAMINES FOR THE TREATMENT OF CONDITIONS ASSOCIATED WITH GSK-3 | AstraZeneca AB (SE) | 2004-05-06 | — | — | EP | claimed |
| WO-2003004472-A1 | ARYLAMINES FOR THE TREATMENT OF CONDITIONS ASSOCIATED WITH GSK-3 | ASTRAZENECA AB (SE) | 2003-01-16 | — | — | WO | claimed |
| EP-1414801-A1 | ARYLAMINES FOR THE TREATMENT OF CONDITIONS ASSOCIATED WITH GSK-3 | AstraZeneca AB (SE) | 2004-05-06 | — | — | EP | disclosed |
| WO-2003004472-A1 | ARYLAMINES FOR THE TREATMENT OF CONDITIONS ASSOCIATED WITH GSK-3 | ASTRAZENECA AB (SE) | 2003-01-16 | — | — | WO | disclosed |