Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 7/20 | 0.63 |
| ▸ | CSNK1D | P48730 | 3/20 | 0.43 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.43 |
| ▸ | CSNK1E | P49674 | 2/20 | 0.43 |
| ▸ | AHR | P35869 | 2/20 | 0.39 |
| ▸ | SRC | P12931 | 2/20 | 0.36 |
| ▸ | BRAF | P15056 | 2/20 | 0.36 |
| ▸ | KDR | P35968 | 2/20 | 0.36 |
| ▸ | GABRP | O00591 | 1/20 | 0.36 |
| ▸ | GABRD | O14764 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.36 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.36 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.36 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.36 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.36 |
| ▸ | GABRE | P78334 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7841690 | 0.88 | MAPK14 (0.51) | MAPK14CSNK1DCSNK1A1CSNK1EAHR | |
| SCHEMBL6592866 | 0.84 | MAPK14 (0.45) | MAPK14AHRNPC1RAB9AKMT2A | |
| SCHEMBL6594341 | 0.83 | MAPK14 (0.45) | MAPK14SMN1; SMN2KMT2A | |
| SCHEMBL7841227 | 0.83 | MAPK14 (0.60) | MAPK14CSNK1DCSNK1A1CSNK1EPTGS2 | |
| SCHEMBL5398429 | 0.82 | MAPK14 (0.63) | MAPK14CSNK1DCSNK1A1CSNK1EAHR | |
| SCHEMBL5364802 | 0.81 | MAPK14 (0.66) | MAPK14CSNK1DCSNK1A1CSNK1EAHR | |
| SCHEMBL5396092 | 0.78 | MAPK14 (0.65) | MAPK14CSNK1DCSNK1A1CSNK1EAHR | |
| SCHEMBL6593792 | 0.78 | CACNA2D1 (0.43) | MAPK14TP53TSHRPTGS2 | |
| SCHEMBL5379814 | 0.75 | MAPK14 (0.61) | MAPK14GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL18198762 | 0.74 | GRIA1 (0.48) | MAPK14CSNK1DCSNK1A1CSNK1EMAPK13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1157025-B1 | PYRAZOLOPYRIDINES | GLAXO GROUP LTD (GB) | 2004-03-10 | — | — | EP | disclosed |
| US-6498166-B1 | POTENT AND SELECTIVE INHIBITORS OF CYCLOOXYGENASE-2; TREATING PAIN, FEVER AND INFLAMMATION | SMITHKLINE BEECHAM CORPORATION | 2002-12-24 | — | — | US | disclosed |