Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 11/20 | 0.46 |
| ▸ | ESR2 | Q92731 | 11/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | APP | P05067 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | MIF | P14174 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6598725 | 0.77 | ESR1 (0.44) | ESR1ESR2APPMAPTNPC1 | |
| SCHEMBL21815162 | 0.77 | MAPT (0.50) | LMNAMAPTNPC1RAB9AKDM4E | |
| SCHEMBL9199893 | 0.76 | ESR1 (0.53) | ESR1ESR2LMNAAPPMAPT | |
| SCHEMBL6598437 | 0.73 | ESR1 (0.50) | ESR1ESR2APPMAPTNPC1 | |
| SCHEMBL17232968 | 0.73 | MAPT (0.56) | ESR1ESR2APPMAPTNPC1 | |
| SCHEMBL8034090 | 0.71 | ESR1 (0.81) | ESR1ESR2APPMAPTNPC1 | |
| SCHEMBL21815077 | 0.71 | MEN1 (0.56) | ESR1ESR2APPMAPTNPC1 | |
| SCHEMBL20865070 | 0.70 | KDM6B (0.46) | ESR1ESR2LMNAMAPTNPC1 | |
| SCHEMBL29783448 | 0.70 | KDM6B (0.46) | ESR1ESR2LMNAMAPTNPC1 | |
| SCHEMBL29999385 | 0.69 | ESR1 (0.61) | ESR1ESR2LMNAAPPMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1230227-B1 | BENZOXA-AND BENZOTHIAZOLYL SULFAMATES AND THEIR USE AS STEROID SULFATASE INHIBITORS | NOVARTIS AG (CH) | 2004-06-23 | — | — | EP | disclosed |
| US-6716865-B1 | SUBSTITUTED AT THE 2 POSITION; A SULFAMATE BOUND VIA OXYGEN TO THE PHENYL PART OF THE RING STRUCTURE; SULFAMOYLATION; STEROID SULFATASE INHIBITOR, ACNE | NOVARTIS AG (CH) | 2004-04-06 | — | — | US | disclosed |