Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 16/20 | 0.55 |
| ▸ | CDK4 | P11802 | 5/20 | 0.49 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | PLK1 | P53350 | 1/20 | 0.46 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | PRKCA | P17252 | 1/20 | 0.46 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.46 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.45 |
| ▸ | GSK3B | P49841 | 2/20 | 0.45 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.45 |
| ▸ | CDK1 | P06493 | 1/20 | 0.45 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.45 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.45 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.45 |
| ▸ | CCND1 | P24385 | 1/20 | 0.45 |
| ▸ | CCND3 | P30281 | 1/20 | 0.45 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5098405 | 0.86 | CDK2 (0.72) | CDK2CDK4KDRPLK1PTK2 | |
| SCHEMBL5104957 | 0.84 | CDK2 (0.60) | CDK2CDK4KDRPLK1PTK2 | |
| SCHEMBL5104874 | 0.83 | CDK2 (0.63) | CDK2CDK4KDRPLK1PTK2 | |
| SCHEMBL6595205 | 0.80 | CDK2 (0.58) | CDK2CDK4PTK2CCNE1KCNH2 | |
| SCHEMBL5105343 | 0.79 | CDK2 (0.69) | CDK2CDK4KDRPLK1PTK2 | |
| SCHEMBL6594510 | 0.79 | CDK2 (0.81) | CDK2CDK4CDK1 | |
| SCHEMBL6595555 | 0.79 | CDK2 (0.57) | CDK2CDK4PTK2CCNE1KCNH2 | |
| SCHEMBL5098885 | 0.76 | CDK2 (0.78) | CDK2CDK4CCNE1KCNH2GSK3B | |
| SCHEMBL6104420 | 0.75 | CDK2 (0.59) | CDK2CDK4KDRPLK1ABL1 | |
| SCHEMBL4025419 | 0.75 | CDK2 (0.64) | CDK2CDK4KDRPLK1PTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1351958-B1 | IMIDAZOLO-5-YL-2-ANILINO-PYRIMIDINES AS AGENTS FOR THE INHIBITION OF THE CELL PROLIFERATION | ASTRAZENECA AB (SE) | 2004-06-16 | — | — | EP | disclosed |