Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 2/20 | 0.66 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | PTPRC | P08575 | 1/20 | 0.41 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.41 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.41 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.41 |
| ▸ | CTNNB1 | P35222 | 3/20 | 0.40 |
| ▸ | WNT3A | P56704 | 3/20 | 0.40 |
| ▸ | CA2 | P00918 | 5/20 | 0.36 |
| ▸ | CA12 | O43570 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.36 |
| ▸ | RELA | Q04206 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6599322 | 0.83 | CYP2A6 (0.46) | CYP2A6DYRK1APTPRCPTPN6PTPN11 | |
| SCHEMBL9432076 | 0.83 | CYP2A6 (0.70) | CYP2A6DYRK1APTPRCPTPN6PTPN11 | |
| SCHEMBL27727596 | 0.79 | CYP2A6 (0.66) | CYP2A6DYRK1APTPRCPTPN6PTPN11 | |
| SCHEMBL29952287 | 0.79 | CYP2A6 (1.00) | CYP2A6DYRK1APTPRCPTPN6PTPN11 | |
| SCHEMBL632443 | 0.79 | CYP2A6 (1.00) | CYP2A6DYRK1APTPRCPTPN6PTPN11 | |
| SCHEMBL13177010 | 0.79 | CYP2A6 (0.66) | CYP2A6DYRK1APTPRCPTPN6PTPN11 | |
| SCHEMBL16693049 | 0.79 | CYP2A6 (0.59) | CYP2A6DYRK1APTPRCPTPN6PTPN11 | |
| SCHEMBL6958287 | 0.76 | CYP2A6 (0.56) | CYP2A6DYRK1APTPRCPTPN6PTPN11 | |
| SCHEMBL6958280 | 0.76 | CYP2A6 (0.56) | CYP2A6DYRK1APTPRCPTPN6PTPN11 | |
| SCHEMBL3795444 | 0.74 | CYP2A6 (0.54) | CYP2A6MEN1KMT2AKDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1385833-A1 | TRIAZINYL AMIDE DERIVATIVES AS ANGIOGENESIS INHIBITORS | Amgen Inc. (US) | 2004-02-04 | — | — | EP | disclosed |
| WO-2002083654-A1 | TRIAZINYL AMIDE DERIVATIVES AS ANGIOGENESIS INHIBITORS | AMGEN INC. (US) | 2002-10-24 | — | — | WO | disclosed |