Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 18/20 | 0.53 |
| ▸ | FLT1 | P17948 | 11/20 | 0.53 |
| ▸ | PDGFRB | P09619 | 9/20 | 0.53 |
| ▸ | KIT | P10721 | 8/20 | 0.53 |
| ▸ | CSF1R | P07333 | 2/20 | 0.47 |
| ▸ | FLT4 | P35916 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 2/20 | 0.44 |
| ▸ | CIT | O14578 | 1/20 | 0.43 |
| ▸ | HLA-A | P04439 | 1/20 | 0.43 |
| ▸ | RET | P07949 | 1/20 | 0.43 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.43 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.43 |
| ▸ | FRK | P42685 | 1/20 | 0.43 |
| ▸ | CDK8 | P49336 | 1/20 | 0.43 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.43 |
| ▸ | STK3 | Q13188 | 1/20 | 0.43 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.43 |
| ▸ | MAP3K19 | Q56UN5 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6600324 | 0.85 | KDR (0.71) | KDRFLT1PDGFRBKITCSF1R | |
| SCHEMBL6503289 | 0.85 | KDR (0.70) | KDRFLT1PDGFRBKITCSF1R | |
| SCHEMBL6481343 | 0.84 | KDR (0.53) | KDRFLT1PDGFRBKITCSF1R | |
| Hydrochloric Acid SCHEMBL6599699 | 0.84 | KDR (0.70) | KDRFLT1PDGFRBKITCSF1R | |
| SCHEMBL6473753 | 0.83 | KDR (0.53) | KDRFLT1PDGFRBKITCSF1R | |
| SCHEMBL6504661 | 0.81 | KDR (0.49) | KDRFLT1PDGFRBKITCSF1R | |
| SCHEMBL1930591 | 0.72 | KDR (0.53) | KDRFLT1PDGFRBKITCSF1R | |
| SCHEMBL6609516 | 0.70 | KDR (0.71) | KDRFLT1PDGFRBKITCSF1R | |
| SCHEMBL905704 | 0.70 | KDR (1.00) | KDRFLT1PDGFRBKITCSF1R | |
| SCHEMBL905586 | 0.70 | KDR (1.00) | KDRFLT1PDGFRBKITCSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1208096-B1 | SUBSTITUTED PYRIDAZINES AND FUSED PYRIDAZINES WITH ANGIOGENESIS INHIBITING ACTIVITY | BAYER AG (US) | 2004-04-28 | — | — | EP | claimed |