Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.47 |
| ▸ | TDO2 | P48775 | 2/20 | 0.47 |
| ▸ | PSEN1 | P49768 | 5/20 | 0.46 |
| ▸ | PSEN2 | P49810 | 5/20 | 0.46 |
| ▸ | APH1B | Q8WW43 | 5/20 | 0.46 |
| ▸ | NCSTN | Q92542 | 5/20 | 0.46 |
| ▸ | APH1A | Q96BI3 | 5/20 | 0.46 |
| ▸ | PSENEN | Q9NZ42 | 5/20 | 0.46 |
| ▸ | TGM2 | P21980 | 1/20 | 0.46 |
| ▸ | FLT3 | P36888 | 1/20 | 0.44 |
| ▸ | CDYL2 | Q8N8U2 | 1/20 | 0.44 |
| ▸ | CDYL | Q9Y232 | 1/20 | 0.44 |
| ▸ | CDY1; CDY1B | Q9Y6F8 | 1/20 | 0.44 |
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.44 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.43 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.43 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4989007 | 0.89 | IDO1 (0.54) | IDO1TDO2PSEN1PSEN2APH1B | |
| SCHEMBL4989006 | 0.89 | IDO1 (0.54) | IDO1TDO2PSEN1PSEN2APH1B | |
| SCHEMBL4997005 | 0.88 | PSEN1 (0.55) | IDO1TDO2PSEN1PSEN2APH1B | |
| SCHEMBL4997002 | 0.88 | PSEN1 (0.55) | IDO1TDO2PSEN1PSEN2APH1B | |
| SCHEMBL5024104 | 0.76 | MAP3K7 (0.52) | IDO1TGM2FLT3ALDH1A1TDP1 | |
| SCHEMBL4991562 | 0.76 | LRRK2 (0.57) | IDO1TDO2PSEN1PSEN2APH1B | |
| SCHEMBL5024106 | 0.76 | MAP3K7 (0.52) | IDO1TGM2FLT3ALDH1A1TDP1 | |
| SCHEMBL4991570 | 0.76 | LRRK2 (0.57) | IDO1TDO2PSEN1PSEN2APH1B | |
| SCHEMBL4990478 | 0.76 | MDM2 (0.61) | IDO1TDO2PSEN1PSEN2APH1B | |
| SCHEMBL4990472 | 0.76 | MDM2 (0.61) | IDO1TDO2PSEN1PSEN2APH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1430048-A1 | 3-(ARYLAMINO)METHYLENE-1, 3-DIHYDRO-2H-INDOL-2-ONES AS KINASE INHIBITORS | Allergan, Inc. (US) | 2004-06-23 | — | — | EP | disclosed |
| WO-2003027102-A1 | 3-(ARYLAMINO)METHYLENE-1, 3-DIHYDRO-2H-INDOL-2-ONES AS KINASE INHIBITORS | ALLERGAN, INC. (US) | 2003-04-03 | — | — | WO | disclosed |