Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ZAP70 | P43403 | 3/20 | 0.46 |
| ▸ | IDO1 | P14902 | 2/20 | 0.45 |
| ▸ | TDO2 | P48775 | 2/20 | 0.45 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.43 |
| ▸ | TGM2 | P21980 | 2/20 | 0.43 |
| ▸ | FLT1 | P17948 | 3/20 | 0.42 |
| ▸ | CDYL2 | Q8N8U2 | 1/20 | 0.42 |
| ▸ | CDYL | Q9Y232 | 1/20 | 0.42 |
| ▸ | CDY1; CDY1B | Q9Y6F8 | 1/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.40 |
| ▸ | KDR | P35968 | 5/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.40 |
| ▸ | AURKA | O14965 | 2/20 | 0.40 |
| ▸ | RET | P07949 | 2/20 | 0.40 |
| ▸ | FLT3 | P36888 | 2/20 | 0.40 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.40 |
| ▸ | STK3 | Q13188 | 2/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.40 |
| ▸ | SRC | P12931 | 2/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4993949 | 0.94 | ZAP70 (0.51) | ZAP70IDO1TDO2LRRK2TGM2 | |
| SCHEMBL4993945 | 0.94 | ZAP70 (0.51) | ZAP70IDO1TDO2LRRK2TGM2 | |
| SCHEMBL4997259 | 0.90 | ZAP70 (0.54) | ZAP70IDO1TDO2LRRK2TGM2 | |
| SCHEMBL4991128 | 0.90 | ZAP70 (0.54) | ZAP70IDO1TDO2LRRK2TGM2 | |
| SCHEMBL4990335 | 0.90 | FLT1 (0.50) | ZAP70IDO1TGM2FLT1FGFR1 | |
| SCHEMBL4990328 | 0.90 | FLT1 (0.50) | ZAP70IDO1TGM2FLT1FGFR1 | |
| SCHEMBL4991358 | 0.87 | KDR (0.50) | ZAP70IDO1TGM2FLT1FGFR1 | |
| SCHEMBL4991346 | 0.87 | KDR (0.50) | ZAP70IDO1TGM2FLT1FGFR1 | |
| SCHEMBL6611744 | 0.86 | ZAP70 (0.44) | ZAP70IDO1TDO2LRRK2TGM2 | |
| SCHEMBL6611740 | 0.86 | ZAP70 (0.44) | ZAP70IDO1TDO2LRRK2TGM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1430048-A1 | 3-(ARYLAMINO)METHYLENE-1, 3-DIHYDRO-2H-INDOL-2-ONES AS KINASE INHIBITORS | Allergan, Inc. (US) | 2004-06-23 | — | — | EP | disclosed |
| WO-2003027102-A1 | 3-(ARYLAMINO)METHYLENE-1, 3-DIHYDRO-2H-INDOL-2-ONES AS KINASE INHIBITORS | ALLERGAN, INC. (US) | 2003-04-03 | — | — | WO | disclosed |