Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 16/20 | 0.70 |
| ▸ | MAPK13 | O15264 | 8/20 | 0.69 |
| ▸ | MAPK12 | P53778 | 8/20 | 0.69 |
| ▸ | MAPK11 | Q15759 | 8/20 | 0.69 |
| ▸ | GCGR | P47871 | 6/20 | 0.65 |
| ▸ | ALOX5 | P09917 | 5/20 | 0.65 |
| ▸ | CSNK1D | P48730 | 4/20 | 0.59 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.59 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.59 |
| ▸ | FRK | P42685 | 2/20 | 0.59 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.59 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.59 |
| ▸ | GSK3B | P49841 | 2/20 | 0.59 |
| ▸ | PRKD2 | Q9BZL6 | 2/20 | 0.59 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.59 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.59 |
| ▸ | BRAF | P15056 | 1/20 | 0.58 |
| ▸ | CSNK1E | P49674 | 2/20 | 0.57 |
| ▸ | LCK | P06239 | 1/20 | 0.56 |
| ▸ | RET | P07949 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11469982 | 0.82 | MAPK14 (0.69) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL4467677 | 0.82 | MAPK14 (1.00) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL13712659 | 0.82 | MAPK14 (1.00) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL4460547 | 0.82 | MAPK14 (1.00) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL4464755 | 0.81 | MAPK14 (0.80) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL4091788 | 0.79 | MAPK14 (0.65) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL4552316 | 0.79 | MAPK14 (1.00) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL9195042 | 0.79 | MAPK14 (1.00) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL4459150 | 0.78 | MAPK14 (0.76) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL11502760 | 0.78 | MAPK14 (0.73) | MAPK14MAPK13MAPK12MAPK11GCGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1396491-A2 | 2-substituted 4,5-diaryl-imidazoles and their use as p38 MAP kinase inhibitors | Novartis AG (CH) | 2004-03-10 | — | — | EP | claimed |
| EP-0993456-A1 | 2-SUBSTITUTED 4,5-DIARYL IMIDAZOLES | Novartis AG (CH) | 2000-04-19 | — | — | EP | claimed |
| WO-1999001449-A1 | 2-SUBSTITUTED 4,5-DIARYL IMIDAZOLES | NOVARTIS AG (CH) | 1999-01-14 | — | — | WO | claimed |