SCHEMBL6599718

SCHEMBL6599718

COc1cc(C(=O)N(C)CC(CCN2CCCN(c3nc4ccccc4n3Cc3ccoc3)CC2)c2ccc(C(F)(F)F)cc2)cc(OC)c1OC

nearest known ligand 0.39

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
HRH1 P35367 5/20 0.39
TACR2 P21452 5/20 0.36
CYP2D6 P10635 2/20 0.35
KCNH2 Q12809 2/20 0.35
HTR1A P08908 1/20 0.34
TACR1 P25103 2/20 0.34
TACR3 P29371 1/20 0.34
CHRM1 P11229 2/20 0.34
SLC29A1 Q99808 1/20 0.34
ALDH1A1 P00352 1/20 0.34
LMNA P02545 1/20 0.34
MAPT P10636 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6597062 0.94 HRH1 (0.36) HRH1TACR2CYP2D6KCNH2CHRM1
SCHEMBL6596477 0.94 HRH1 (0.39) HRH1TACR2CYP2D6KCNH2TACR1
SCHEMBL6599725 0.93 TACR2 (0.39) HRH1TACR2CYP2D6KCNH2TACR1
SCHEMBL6598013 0.93 HRH1 (0.38) HRH1TACR2CYP2D6KCNH2TACR1
SCHEMBL6596875 0.93 MAPT (0.41) HRH1TACR2CYP2D6KCNH2TACR1
SCHEMBL6596076 0.92 TACR2 (0.40) HRH1TACR2CYP2D6KCNH2TACR1
SCHEMBL6596733 0.92 TACR2 (0.39) HRH1TACR2TACR1TACR3SLC29A1
SCHEMBL6598410 0.91 TACR2 (0.38) HRH1TACR2CYP2D6TACR1TACR3
SCHEMBL6596484 0.91 TACR2 (0.39) HRH1TACR2CYP2D6KCNH2TACR1
SCHEMBL6598213 0.90 HRH1 (0.41) HRH1TACR2HTR1ATACR1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0888338-B1 NOVEL SUBSTITUTED N-METHYL-N-(4-(4-(1H-BENZIMIDAZOL-2-YL) 1,4]DIAZEPAN-1-YL)-2-(ARYL)BUTYL)BENZAMIDES USEFUL FOR THE TREATMENT OF ALLERGIC DISEASES AVENTIS PHARMA INC (US) 2004-11-17 EP disclosed
EP-0888338-A1 NOVEL SUBSTITUTED N-METHYL-N-(4-(4-(1H-BENZIMIDAZOL-2-YL) 1,4]DIAZEPAN-1-YL)-2-(ARYL)BUTYL)BENZAMIDES USEFUL FOR THE TREATMENT OF ALLERGIC DISEASES HOECHST MARION ROUSSEL, INC. (US) 1999-01-07 EP disclosed
WO-1997030991-A1 NOVEL SUBSTITUTED N-METHYL-N-(4-(4-(1H-BENZIMIDAZOL-2-YL)[1,4]DIAZEPAN-1-YL)-2-(ARYL)BUTYL)BENZAMIDES USEFUL FOR THE TREATMENT OF ALLERGIC DISEASES HOECHST MARION ROUSSEL, INC. (US) 1997-08-28 WO disclosed