Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 16/20 | 0.54 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.42 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.42 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.42 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4700524 | 0.81 | NPC1 (0.57) | PARP1RAB9ATP53MAPTNPC1 | |
| SCHEMBL4698434 | 0.81 | PARP1 (0.61) | PARP1KDM4EALDH1A1 | |
| SCHEMBL4697702 | 0.80 | PARP1 (0.51) | PARP1MAPT | |
| SCHEMBL4703307 | 0.80 | PARP1 (0.46) | PARP1 | |
| SCHEMBL4701035 | 0.79 | PARP1 (0.45) | PARP1MAPTNPC1KDM4EALDH1A1 | |
| SCHEMBL4699083 | 0.79 | PARP1 (0.47) | PARP1TP53MAPTATMNPC1 | |
| SCHEMBL4699395 | 0.78 | CYP3A4 (0.48) | PARP1RAB9AMAPTNPC1KDM4E | |
| SCHEMBL4697754 | 0.77 | AURKB (0.54) | PARP1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL4699412 | 0.76 | PARP1 (0.50) | PARP1RAB9ATP53MAPTNPC1 | |
| SCHEMBL4700145 | 0.75 | PARP1 (0.48) | PARP1RAB9AMAPTNPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1427708-A1 | AMINO-PHTHALAZINONE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Pharmacia Italia S.p.A. (IT) | 2004-06-16 | — | — | EP | claimed |
| WO-2003014090-A1 | AMINO-PHTHALAZINONE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | PHARMACIA ITALIA S.P.A. (IT) | 2003-02-20 | — | — | WO | claimed |