Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.46 |
| ▸ | GAA | P10253 | 4/20 | 0.46 |
| ▸ | GLA | P06280 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 4/20 | 0.42 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | PDE3B | Q13370 | 4/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.42 |
| ▸ | P2RY12 | Q9H244 | 3/20 | 0.42 |
| ▸ | PDE2A | O00408 | 2/20 | 0.42 |
| ▸ | HRH2 | P25021 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6484943 | 0.94 | PDE3B (0.48) | KDM4EGAAGLAHTTHPGD | |
| SCHEMBL6474606 | 0.91 | KDM4E (0.49) | KDM4EGAAGLAHTTHPGD | |
| SCHEMBL6526290 | 0.82 | CYP11B1 (0.43) | PLA2G2ALMNAPDE3BPDE3AP2RY12 | |
| SCHEMBL6484336 | 0.81 | PDE3B (0.50) | KDM4EHPGDSMN1; SMN2ALDH1A1PDE3B | |
| SCHEMBL6481683 | 0.80 | PDE3B (0.49) | KDM4ESMN1; SMN2ALDH1A1PDE3BPDE3A | |
| SCHEMBL6484254 | 0.79 | PDE3B (0.50) | KDM4EGAAHPGDSMN1; SMN2NPSR1 | |
| SCHEMBL6485249 | 0.79 | PDE3B (0.50) | KDM4ESMN1; SMN2RXFP1ALDH1A1PDE3B | |
| SCHEMBL6480715 | 0.78 | PDE3B (0.50) | KDM4EHPGDALDH1A1HSD17B10PDE3B | |
| SCHEMBL6484869 | 0.78 | PDE3B (0.49) | KDM4ESMN1; SMN2ALDH1A1PDE3BPDE3A | |
| SCHEMBL6476128 | 0.78 | HPGD (0.55) | KDM4EHPGDSMN1; SMN2ALDH1A1PDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1404321-A1 | 1-ALKYL-2-ARYL-BENZIMIDAZOLE DERIVATIVES, THEIR USE FOR PRODUCING MEDICAMENTS AND PHARMACEUTICAL PREPARATIONS CONTAINING SAID DERIVATIVES | Schering Aktiengesellschaft (DE) | 2004-04-07 | — | — | EP | disclosed |
| WO-2003004023-A1 | 1-ALKYL-2-ARYL-BENZIMIDAZOLE DERIVATIVES, THEIR USE FOR PRODUCING MEDICAMENTS AND PHARMACEUTICAL PREPARATIONS CONTAINING SAID DERIVATIVES | SCHERING AKTIENGESELLSCHAFT (DE) | 2003-01-16 | — | — | WO | disclosed |