Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 12/20 | 0.40 |
| ▸ | F10 | P00742 | 3/20 | 0.39 |
| ▸ | ITGB3 | P05106 | 3/20 | 0.37 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.37 |
| ▸ | PRSS2 | P07478 | 3/20 | 0.37 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.37 |
| ▸ | PRSS3 | P35030 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6603571 | 0.91 | GRM2 (0.47) | GRM2F10ITGB3PRSS1PRSS2 | |
| SCHEMBL6601386 | 0.90 | GRM2 (0.44) | GRM2F10ITGB3PRSS1PRSS2 | |
| SCHEMBL6601234 | 0.90 | GRM2 (0.49) | GRM2F10ITGB3PRSS1PRSS2 | |
| SCHEMBL6605363 | 0.90 | F10 (0.50) | GRM2F10ITGB3ITGA2B | |
| SCHEMBL6601789 | 0.89 | GRM2 (0.45) | GRM2F10ITGB3PRSS1PRSS2 | |
| SCHEMBL6600718 | 0.89 | GRM2 (0.45) | GRM2F10ITGB3PRSS1PRSS2 | |
| SCHEMBL6600722 | 0.89 | GRM2 (0.45) | GRM2F10ITGB3PRSS1PRSS2 | |
| SCHEMBL6603720 | 0.89 | GRM2 (0.49) | GRM2F10 | |
| SCHEMBL6601309 | 0.89 | GRM2 (0.49) | GRM2F10 | |
| SCHEMBL6601219 | 0.89 | GRM2 (0.50) | GRM2NPC1ALDH1A1PKMRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0741133-B1 | Adhesion receptor antagonists | MERCK PATENT GMBH (DE) | 2004-01-28 | — | — | EP | disclosed |
| EP-0741133-A2 | Adhesion receptor antagonists | MERCK PATENT GmbH (DE) | 1996-11-06 | — | — | EP | disclosed |