Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 13/20 | 0.52 |
| ▸ | PDE4D | Q08499 | 13/20 | 0.52 |
| ▸ | PDE4A | P27815 | 12/20 | 0.52 |
| ▸ | PDE4C | Q08493 | 12/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.45 |
| ▸ | PGR | P06401 | 2/20 | 0.44 |
| ▸ | PDE5A | O76074 | 1/20 | 0.44 |
| ▸ | PDE1A | P54750 | 1/20 | 0.44 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.44 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6603243 | 0.93 | PDE4B (0.52) | PDE4BPDE4DPDE4APDE4CPOLB | |
| SCHEMBL143369 | 0.93 | PDE4B (0.48) | PDE4BPDE4DPDE4APDE4CPOLB | |
| SCHEMBL6602606 | 0.91 | MAOB (0.55) | PDE4BPOLBALDH1A1MAOBPGR | |
| SCHEMBL6602063 | 0.91 | PDE4B (0.52) | PDE4BPDE4DPDE4APDE4CPOLB | |
| SCHEMBL6602010 | 0.89 | PDE4B (0.52) | PDE4BPDE4DPDE4APDE4CALDH1A1 | |
| SCHEMBL6602284 | 0.88 | PDE4D (0.51) | PDE4BPDE4DPDE4APDE4CPOLB | |
| Hydrochloric Acid SCHEMBL7649060 | 0.88 | PDE4B (0.51) | PDE4BPDE4DPDE4APDE4CPDE5A | |
| SCHEMBL6602629 | 0.87 | PDE4B (0.55) | PDE4BPDE4DPDE4APDE4CPOLB | |
| SCHEMBL6603355 | 0.87 | PDE4D (0.51) | PDE4BPDE4DPDE4APDE4CPOLB | |
| SCHEMBL6604019 | 0.86 | MAPT (0.50) | PDE4BPDE4DPDE4APDE4CPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0922036-B1 | ARYLALKANOYL PYRIDAZINES | MERCK PATENT GMBH (DE) | 2004-03-24 | — | — | EP | disclosed |
| US-6479494-B1 | THEY INHIBIT SELECTIVELY PHOSPHODIESTERASE IV, WHICH CAUSES AN INCREASE OF THE INTRACELLULAR CAMP LEVEL AS CAMP INHIBITS BONE DECREASING CELLS AND STIMULATES BONE INCREASING CELLS FOR TREATMENT OF OSTEOPOROSIS | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 2002-11-12 | — | — | US | disclosed |
| EP-1143944-A3 | USE OF ARYLALKANOYLPYRIDAZINES | MERCK PATENT GmbH (DE) | 2002-09-11 | — | — | EP | disclosed |
| EP-1143944-A2 | USE OF ARYLALKANOYLPYRIDAZINES | MERCK PATENT GmbH (DE) | 2001-10-17 | — | — | EP | disclosed |
| WO-2000059484-A2 | USE OF ARYLALKANOYLPYRIDAZINES | MERCK PATENT GMBH (DE) | 2000-10-12 | — | — | WO | disclosed |
| US-6107295-A | Arylalkanoyl pyridazines | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2000-08-22 | — | — | US | disclosed |
| EP-0922036-A1 | ARYLALKANOYL PYRIDAZINES | MERCK PATENT GmbH (DE) | 1999-06-16 | — | — | EP | disclosed |
| WO-1998006704-A1 | ARYLALKANOYL PYRIDAZINES | MERCK PATENT GMBH (DE) | 1998-02-19 | — | — | WO | disclosed |