Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 19/20 | 0.59 |
| ▸ | ESR2 | Q92731 | 18/20 | 0.59 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | PLD2 | O14939 | 1/20 | 0.50 |
| ▸ | KDM1A | O60341 | 1/20 | 0.50 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | C5 | P01031 | 1/20 | 0.50 |
| ▸ | FYN | P06241 | 1/20 | 0.50 |
| ▸ | PGR | P06401 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6603713 | 0.85 | ESR1 (0.61) | ESR1ESR2ENPP3MEN1ALDH1A1 | |
| SCHEMBL9201123 | 0.75 | ESR1 (0.90) | ESR1ESR2ENPP3MEN1ALDH1A1 | |
| SCHEMBL7752984 | 0.73 | ESR1 (1.00) | ESR1ESR2MEN1ALDH1A1LMNA | |
| SCHEMBL6838523 | 0.73 | ESR1 (1.00) | ESR1ESR2MEN1ALDH1A1LMNA | |
| SCHEMBL11191993 | 0.73 | ESR1 (0.66) | ESR1ESR2ENPP3MEN1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL9200978 | 0.73 | ESR1 (1.00) | ESR1ESR2MEN1ALDH1A1LMNA | |
| SCHEMBL6601788 | 0.73 | ESR1 (0.69) | ESR1ESR2ENPP3MEN1ALDH1A1 | |
| SCHEMBL6601541 | 0.73 | ESR1 (0.68) | ESR1ESR2MEN1ALDH1A1LMNA | |
| SCHEMBL6600538 | 0.72 | ESR1 (0.63) | ESR1ESR2ENPP3CNR1 | |
| SCHEMBL6601121 | 0.72 | ESR1 (0.51) | ESR1ESR2ENPP3MEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0905132-B1 | Benzothiophenes | LILLY CO ELI (US) | 2004-08-04 | — | — | EP | disclosed |
| US-6060488-A | ANTICARCINOGENIC AGENTS; POSTMENOPAUSAL CANCER OF BREASTS, UTERUS, CERVIX | ELI LILLY AND COMPANY (US) | 2000-05-09 | — | — | US | disclosed |
| EP-0905132-A1 | Benzothiophenes | ELI LILLY AND COMPANY (US) | 1999-03-31 | — | — | EP | disclosed |