Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.49 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA7 | P43166 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CRHBP | P24387 | 1/20 | 0.39 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8688056 | 0.82 | IDO1 (0.63) | IDO1AKR1C3CA12CA1CA2 | |
| SCHEMBL6754023 | 0.81 | IDO1 (0.54) | IDO1AKR1C3HTR2ACA12CA1 | |
| SCHEMBL6754021 | 0.81 | IDO1 (0.54) | IDO1AKR1C3HTR2ACA12CA1 | |
| SCHEMBL14247542 | 0.81 | IDO1 (0.50) | IDO1AKR1C3HTR2ACA12CA1 | |
| SCHEMBL12646388 | 0.78 | IDO1 (0.54) | IDO1AKR1C3CA12CA1CA2 | |
| SCHEMBL4869141 | 0.78 | TSHR (0.39) | IDO1CA1CA2CA9ALDH1A1 | |
| SCHEMBL11569397 | 0.74 | IDO1 (0.61) | IDO1AKR1C3CA12CA1CA2 | |
| SCHEMBL6753829 | 0.73 | KCNH2 (0.49) | IDO1LOXL2KCNH2 | |
| SCHEMBL17662368 | 0.73 | IDO1 (0.59) | IDO1AKR1C3HTR2ACA12CA1 | |
| SCHEMBL8688058 | 0.73 | IDO1 (0.59) | IDO1AKR1C3CA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0924210-B1 | 2-(1-(1,3-Thiazolin-2-yl)azetidin-3-yl)thio-carbapenem derivatives | WYETH K K (JP) | 2004-08-18 | — | — | EP | disclosed |
| EP-0632039-B1 | 2-[1-(1,3-Thiazolin-2-yl)azetidin-3-yl]thio-carbapenem derivatives | WYETH LEDERLE JAPAN LTD (JP) | 2002-01-30 | — | — | EP | disclosed |
| EP-0924210-A1 | 2-(1-(1,3-Thiazolin-2-yl)azetidin-3-yl)thio-carbapenem derivatives | LEDERLE (JAPAN), Ltd. (JP) | 1999-06-23 | — | — | EP | disclosed |
| US-5783703-A | CARBAPENEM INTERMEDIATES | LEDERLE (JAPAN), LTD. (JP) | 1998-07-21 | — | — | US | disclosed |
| US-5679790-A | ANTIBIOTICS, BACTERICIDES | LEDERLE (JAPAN), LTD. (JP) | 1997-10-21 | — | — | US | disclosed |
| US-5534510-A | ORALLY ADMINISTRABLE THIENAMYCIN ANTIBIOTICS; BETA-LACTAMASE INHIBITORS | LEDERLE (JAPAN), LTD. (JP) | 1996-07-09 | — | — | US | disclosed |
| EP-0632039-A1 | 2-(1-(1,3-Thiazolin-2-yl)azetidin-3-yl)thio-carbapenem derivatives | LEDERLE (JAPAN), Ltd. (JP) | 1995-01-04 | — | — | EP | disclosed |