SCHEMBL6601940

SCHEMBL6601940

COc1ccc(C(=O)Nc2ccc3c(c2Cl)CN(CCO)CC3)cc1C(F)(F)F

nearest known ligand 0.43

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
ABCG2 Q9UNQ0 6/20 0.43
ABCB1 P08183 5/20 0.43
NTRK1 P04629 1/20 0.42
MAPT P10636 3/20 0.41
PDCD1 Q15116 4/20 0.40
CD274 Q9NZQ7 4/20 0.40
HTR2A P28223 1/20 0.40
HTR2C P28335 1/20 0.40
HTR2B P41595 1/20 0.40
BRAF P15056 2/20 0.39
RAF1 P04049 1/20 0.39
PDE4D Q08499 1/20 0.39
TP53 P04637 1/20 0.39
GAA P10253 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8135861 0.93 ABCG2 (0.39) ABCG2ABCB1NTRK1MAPTPDCD1
SCHEMBL6601028 0.89 HDAC8 (0.45) MAPTBRAFRAF1PDE4DTP53
SCHEMBL6601429 0.88 ABCG2 (0.39) ABCG2ABCB1MAPTHTR2AHTR2C
SCHEMBL6601821 0.84 MAPT (0.42) ABCB1MAPTHTR2AHTR2CHTR2B
SCHEMBL6602418 0.84 ESR1 (0.47) ABCB1MAPTHTR2AHTR2CHTR2B
SCHEMBL6601437 0.84 MAPT (0.37) ABCG2ABCB1MAPTHTR2AHTR2C
SCHEMBL6602605 0.84 MAPT (0.48) MAPTPDE4DTP53GAA
SCHEMBL6601425 0.79 BRAF (0.37) MAPTHTR2AHTR2CHTR2BBRAF
SCHEMBL6602301 0.79 HDAC8 (0.48) MAPTHTR2ABRAFRAF1PDE4D
SCHEMBL6602603 0.79 HDAC8 (0.46) MAPTBRAFRAF1PDE4DTP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1395251-A2 AMINEDIOLS AS AGENTS FOR THE TREATMENT OF ALZHEIMER'S DISEASE Elan Pharmaceuticals, Inc. (US) 2004-03-10 EP claimed
EP-1042296-B1 SUBSTITUTED ISOQUINOLINE DERIVATIVES AND THEIR USE AS ANTICONVULSANTS SMITHKLINE BEECHAM PLC (GB) 2004-02-25 EP claimed
WO-2002100818-A2 AMINEDIOLS AS AGENTS FOR THE TREATMENT OF ALZHEIMER'S DISEASE ELAN PHARMACEUTICALS, INC. (US) 2002-12-19 WO claimed
US-6248754-B1 PSYCHOLOGICAL DISORDERS SMITHKLINE BEECHAM, P.L.C. (GB) 2001-06-19 US claimed
EP-1042296-B1 SUBSTITUTED ISOQUINOLINE DERIVATIVES AND THEIR USE AS ANTICONVULSANTS SMITHKLINE BEECHAM PLC (GB) 2004-02-25 EP disclosed
US-6248754-B1 PSYCHOLOGICAL DISORDERS SMITHKLINE BEECHAM, P.L.C. (GB) 2001-06-19 US disclosed
EP-1042296-A1 SUBSTITUTED ISOQUINOLINE DERIVATIVES AND THEIR USE AS ANTICONVULSANTS SMITHKLINE BEECHAM PLC (GB) 2000-10-11 EP disclosed
WO-1999031068-A1 SUBSTITUTED ISOQUINOLINE DERIVATIVES AND THEIR USE AS ANTICONVULSANTS SMITHKLINE BEECHAM PLC (GB) 1999-06-24 WO disclosed