Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 13/20 | 0.56 |
| ▸ | ESR2 | Q92731 | 13/20 | 0.56 |
| ▸ | CNR1 | P21554 | 1/20 | 0.52 |
| ▸ | CNR2 | P34972 | 1/20 | 0.52 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.49 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.48 |
| ▸ | TUBB | P07437 | 1/20 | 0.48 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.48 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.48 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.48 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.48 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.48 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.48 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.48 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.48 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.48 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.48 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.48 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.48 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6600990 | 0.95 | ESR1 (0.58) | ESR1ESR2CNR1CNR2CHEK2 | |
| SCHEMBL6601476 | 0.89 | ESR1 (0.66) | ESR1ESR2CNR1ACHE | |
| SCHEMBL6602854 | 0.88 | ESR1 (0.65) | ESR1ESR2CNR1CNR2ENPP3 | |
| SCHEMBL6600800 | 0.85 | ESR1 (0.61) | ESR1ESR2CNR1CNR2TUBB4A | |
| SCHEMBL6602789 | 0.84 | ESR1 (0.62) | ESR1ESR2CNR1CNR2TUBB4A | |
| SCHEMBL6601827 | 0.84 | ESR1 (0.70) | ESR1ESR2CNR1ACHE | |
| SCHEMBL6603461 | 0.84 | ESR1 (0.63) | ESR1ESR2CNR1CNR2TUBB4A | |
| SCHEMBL8490502 | 0.82 | CHEK2 (0.53) | CHEK2BCHEACHE | |
| SCHEMBL6601882 | 0.81 | ESR1 (0.56) | ESR1ESR2CNR1ACHE | |
| SCHEMBL6601102 | 0.81 | ESR1 (0.61) | ESR1ESR2CNR1CNR2TUBB4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0905132-B1 | Benzothiophenes | LILLY CO ELI (US) | 2004-08-04 | — | — | EP | disclosed |
| US-6060488-A | ANTICARCINOGENIC AGENTS; POSTMENOPAUSAL CANCER OF BREASTS, UTERUS, CERVIX | ELI LILLY AND COMPANY (US) | 2000-05-09 | — | — | US | disclosed |
| EP-0905132-A1 | Benzothiophenes | ELI LILLY AND COMPANY (US) | 1999-03-31 | — | — | EP | disclosed |