Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX4 | Q99571 | 1/20 | 0.32 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.31 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.31 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.31 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28034490 | 0.78 | USP2 (0.34) | — | |
| SCHEMBL27571019 | 0.78 | P2RX4 (0.37) | P2RX4TSHR | |
| SCHEMBL5195768 | 0.77 | — | — | |
| SCHEMBL27336385 | 0.77 | — | — | |
| SCHEMBL30754221 | 0.72 | — | — | |
| SCHEMBL29570290 | 0.69 | P2RX4 (0.33) | P2RX4 | |
| SCHEMBL27828912 | 0.69 | TSHR (0.35) | TSHR | |
| SCHEMBL7446771 | 0.68 | P2RX4 (0.33) | P2RX4 | |
| SCHEMBL11662882 | 0.68 | — | — | |
| SCHEMBL6464636 | 0.68 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116888126-A | Compound of casein kinase inhibitor | 北京原基华毅生物科技有限公司 | 2023-10-13 | — | — | CN | disclosed |
| CN-111032046-B | Pyruvate kinase modulators and uses thereof | 安吉奥斯医药品有限公司 | 2023-09-26 | — | — | CN | disclosed |
| CN-114302886-A | Triazolopyridazine derivative, preparation method, pharmaceutical composition and application thereof | 上海赛默罗生物科技有限公司 | 2022-04-08 | — | — | CN | disclosed |
| CN-113646050-A | Thieno [3,2-B ] pyrrolo [3,2-D ] pyridazinone derivatives and their use as PKM2 derivatives for the treatment of cancer, obesity and diabetes related disorders | 安吉奥斯医药品有限公司 | 2021-11-12 | — | — | CN | disclosed |
| CN-107635992-B | Tricyclic heterocyclic compounds useful as TNF inhibitors | 百时美施贵宝公司 | 2020-05-22 | — | — | CN | disclosed |
| CN-111032046-A | Pyruvate kinase modulators and uses thereof | 安吉奥斯医药品有限公司 | 2020-04-17 | — | — | CN | disclosed |
| CN-107635992-A | Tricyclic heterocyclic compounds useful as TNF inhibitors | 百时美施贵宝公司 | 2018-01-26 | — | — | CN | disclosed |
| EP-2916842-B1 | TRIAZOLO COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2016-10-19 | — | — | EP | disclosed |
| EP-2916842-A1 | TRIAZOLO COMPOUNDS | F. Hoffmann-La Roche AG (CH) | 2015-09-16 | — | — | EP | disclosed |
| CN-102124005-B | Cmet inhibitors | TAKEDA PHARMACEUTICAL | 2014-06-04 | — | — | CN | disclosed |
| WO-2014072261-A1 | TRIAZOLO COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2014-05-15 | — | — | WO | disclosed |
| CN-102124005-A | Cmet inhibitors | TAKEDA PHARMACEUTICAL | 2011-07-13 | — | — | CN | disclosed |
| CN-101842098-A | Nitrogen-containing bicyclic chemical entities for the treatment of viral infections | GENELABS TECH INC | 2010-09-22 | — | — | CN | disclosed |
| EP-1102757-B1 | SUBSTITUTED OXAZOLE AND THIAZOLE DERIVATIVES AS HPPAR GAMMA AND HPPAR ALPHA ACTIVATORS | GLAXO GROUP LTD (GB) | 2004-04-14 | — | — | EP | disclosed |
| CN-1413112-A | Nasal drops containing fused pyridazine derivatives | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-04-23 | — | — | CN | disclosed |
| US-6498174-B1 | AGONISTS TO PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS; MODULATING BLOOD GLUCOSE AND LIPID LEVELS; REDUCING DYSLIPIDEMIA AND HYPERINSULINEMIA ASSOCIATED WITH IMPAIRED GLUCOSE TOLERANCE OR METABOLIC SYNDROME | SMITHKLINE BEECHAM CORPORATION | 2002-12-24 | — | — | US | disclosed |
| CN-1329614-A | Fused pyridazine derivatives, process for preparation of same and uses thereof | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2002-01-02 | — | — | CN | disclosed |
| EP-1102757-A1 | SUBSTITUTED OXAZOLE AND THIAZOLE DERIVATIVES AS HPPAR GAMMA AND HPPAR ALPHA ACTIVATORS | GLAXO GROUP LIMITED (GB) | 2001-05-30 | — | — | EP | disclosed |
| CN-1248259-A | Fused pyridazine derivatives, process for producing the same and use thereof | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2000-03-22 | — | — | CN | disclosed |
| WO-2000008002-A1 | SUBSTITUTED OXAZOLES AND THIAZOLES DERIVATIVES AS hPPAR GAMMA AND hPPAR ALPHA ACTIVATORS | GLAXO GROUP LIMITED (GB) | 2000-02-17 | — | — | WO | disclosed |