Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 6/20 | 0.63 |
| ▸ | GRIA2 | P42262 | 6/20 | 0.63 |
| ▸ | GRIA3 | P42263 | 6/20 | 0.63 |
| ▸ | GRIA4 | P48058 | 6/20 | 0.63 |
| ▸ | GRIK1 | P39086 | 2/20 | 0.54 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.54 |
| ▸ | GRIK3 | Q13003 | 2/20 | 0.54 |
| ▸ | GRIK4 | Q16099 | 2/20 | 0.54 |
| ▸ | GRIK5 | Q16478 | 2/20 | 0.54 |
| ▸ | NAMPT | P43490 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6602695 | 0.89 | GRIA1 (0.79) | GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL6607049 | 0.88 | GRIA1 (0.81) | GRIA1GRIA2GRIA3GRIA4GRIK1 | |
| SCHEMBL6602666 | 0.87 | GRIA1 (0.77) | GRIA1GRIA2GRIA3GRIA4GRIK1 | |
| SCHEMBL6603091 | 0.83 | GRIA1 (0.57) | GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL6608183 | 0.83 | GRIA1 (0.75) | GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL6602498 | 0.82 | GRIA1 (0.71) | GRIA1GRIA2GRIA3GRIA4GRIK1 | |
| SCHEMBL6603448 | 0.82 | GRIA1 (0.72) | GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL6606394 | 0.81 | GRIA1 (0.70) | GRIA1GRIA2GRIA3GRIA4GRIK1 | |
| SCHEMBL6602684 | 0.81 | GRIA1 (0.64) | GRIA1GRIA2GRIA3GRIA4GRIK1 | |
| SCHEMBL6601994 | 0.81 | GRIA1 (0.70) | GRIA1GRIA2GRIA3GRIA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1020453-B1 | 6,7-ASYMMETRICALLY DISUBSTITUTED QUINOXALINECARBOXYLIC ACID DERIVATIVES, ADDITION SALTS THEREOF, AND PROCESSES FOR THE PREPARATION OF BOTH | KYORIN SEIYAKU KK (JP) | 2004-05-19 | — | — | EP | disclosed |
| US-6348461-B1 | CENTRAL NERVOUS SYSTEM ANTAGONIST WITH HETEROCYCLIC SUBSTITUENTS | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2002-02-19 | — | — | US | disclosed |
| EP-1020453-A1 | 6,7-ASYMMETRICALLY DISUBSTITUTED QUINOXALINECARBOXYLIC ACID DERI VATIVES, ADDITION SALTS THEREOF, AND PROCESSES FOR THE PREPARATION OF BOTH | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2000-07-19 | — | — | EP | disclosed |