Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 14/20 | 0.76 |
| ▸ | HTR2C | P28335 | 14/20 | 0.76 |
| ▸ | HTR2B | P41595 | 13/20 | 0.76 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.39 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4826880 | 1.00 | HTR2A (0.76) | HTR2AHTR2CHTR2BTLR7CYP3A4 | |
| SCHEMBL4826871 | 1.00 | HTR2A (0.76) | HTR2AHTR2CHTR2BTLR7CYP3A4 | |
| SCHEMBL6603614 | 0.86 | HTR2C (1.00) | HTR2AHTR2CHTR2BTLR7CYP3A4 | |
| SCHEMBL6604307 | 0.86 | HTR2C (1.00) | HTR2AHTR2CHTR2BTLR7CYP3A4 | |
| SCHEMBL6605040 | 0.86 | HTR2C (1.00) | HTR2AHTR2CHTR2BTLR7CYP3A4 | |
| Hydrochloric Acid SCHEMBL6604400 | 0.85 | HTR2C (0.97) | HTR2AHTR2CHTR2BTLR7CYP3A4 | |
| Hydrochloric Acid SCHEMBL6607981 | 0.85 | HTR2C (0.97) | HTR2AHTR2CHTR2BTLR7CYP3A4 | |
| Fumaric Acid SCHEMBL6602929 | 0.80 | HTR2A (0.80) | HTR2AHTR2CHTR2BTLR7PSMB5 | |
| Fumaric Acid SCHEMBL6602921 | 0.80 | HTR2A (0.80) | HTR2AHTR2CHTR2BTLR7PSMB5 | |
| Fumaric Acid SCHEMBL6602840 | 0.80 | HTR2A (0.80) | HTR2AHTR2CHTR2BTLR7PSMB5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1109809-B1 | PYRROLOQUINOLINES FOR TREATMENT OF OBESITY | CEREBRUS PHARM LTD (GB) | 2004-11-17 | — | — | EP | disclosed |
| US-6365598-B1 | FOR THERAPY AND PROPHYLAXIS OF DISORDERS OF THE CENTRAL NERVOUS SYSTEM; DAMAGE TO THE CENTRAL NERVOUS SYSTEM; CARDIOVASCULAR DISORDERS; GASTROINTESTINAL DISORDERS; DIABETES INSIPIDUS; AND SLEEP APNEA | VERNALIS RESEARCH LIMITED (GB) | 2002-04-02 | — | — | US | disclosed |