Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6605960 | 0.92 | MRGPRX4 (0.55) | MRGPRX4 | |
| SCHEMBL6605085 | 0.89 | MRGPRX4 (0.42) | MRGPRX4 | |
| SCHEMBL6606254 | 0.85 | TP53 (0.47) | MRGPRX4EIF4EBP1 | |
| SCHEMBL6602423 | 0.85 | MRGPRX4 (0.51) | MRGPRX4EIF4EBP1 | |
| SCHEMBL6614651 | 0.84 | MRGPRX4 (0.50) | MRGPRX4EIF4EBP1 | |
| SCHEMBL6805954 | 0.83 | MRGPRX4 (0.38) | MRGPRX4 | |
| SCHEMBL6602576 | 0.83 | EIF4EBP1 (0.40) | MRGPRX4EIF4EBP1 | |
| SCHEMBL6607701 | 0.79 | KDM4E (0.46) | MRGPRX4EIF4EBP1 | |
| SCHEMBL6606062 | 0.78 | TP53 (0.46) | MRGPRX4 | |
| SCHEMBL6803407 | 0.78 | TP53 (0.44) | MRGPRX4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040180891-A1 | Pyrazole derivatives useful in the treatment of hyper-proliferative disorders | BAYER PHARMACEUTICALS CORPORATION | 2004-09-16 | — | — | US | disclosed |
| EP-1432689-A1 | PYRAZOLE DERIVATIVES USEFUL IN THE TREATMENT OF HYPER-PROLIFERATIVE DISORDERS | Bayer Corporation (US) | 2004-06-30 | — | — | EP | disclosed |
| WO-2003027074-A1 | PYRAZOLE DERIVATIVES USEFUL IN THE TREATMENT OF HYPER-PROLIFERATIVE DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040180891-A1 | Pyrazole derivatives useful in the treatment of hyper-proliferative disorders | MKI67, CDK4, FLT4 | MRGPRX4 2245/4885EIF4EBP1 2524/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.