Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | TARBP2 | Q15633 | 1/20 | 0.51 |
| ▸ | PPARG | P37231 | 5/20 | 0.49 |
| ▸ | PPARA | Q07869 | 4/20 | 0.49 |
| ▸ | PPARD | Q03181 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6606824 | 0.92 | SMN1; SMN2 (0.59) | SMN1; SMN2KDM4ETARBP2PPARGPPARA | |
| SCHEMBL6437060 | 0.86 | KDM4E (0.72) | SMN1; SMN2KDM4ETARBP2PPARGPPARA | |
| SCHEMBL820909 | 0.84 | SMN1; SMN2 (0.61) | SMN1; SMN2KDM4ETARBP2PPARDHSD17B10 | |
| SCHEMBL13115711 | 0.82 | SMN1; SMN2 (0.56) | SMN1; SMN2KDM4ETARBP2PPARGHSD17B10 | |
| SCHEMBL11009182 | 0.82 | SMN1; SMN2 (0.56) | SMN1; SMN2KDM4ETARBP2PPARGPPARA | |
| SCHEMBL4034186 | 0.80 | PPARA (0.47) | SMN1; SMN2KDM4ETARBP2PPARGPPARA | |
| SCHEMBL11078937 | 0.80 | SMN1; SMN2 (0.54) | SMN1; SMN2KDM4ETARBP2PPARGPPARA | |
| SCHEMBL2817791 | 0.80 | SMN1; SMN2 (0.54) | SMN1; SMN2KDM4ETARBP2PPARGPPARA | |
| SCHEMBL11004559 | 0.79 | HSD17B10 (0.57) | SMN1; SMN2KDM4ETARBP2PPARGPPARA | |
| SCHEMBL10722521 | 0.79 | SMN1; SMN2 (0.53) | SMN1; SMN2KDM4ETARBP2PPARGHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1102757-B1 | SUBSTITUTED OXAZOLE AND THIAZOLE DERIVATIVES AS HPPAR GAMMA AND HPPAR ALPHA ACTIVATORS | GLAXO GROUP LTD (GB) | 2004-04-14 | — | — | EP | disclosed |
| US-6498174-B1 | AGONISTS TO PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS; MODULATING BLOOD GLUCOSE AND LIPID LEVELS; REDUCING DYSLIPIDEMIA AND HYPERINSULINEMIA ASSOCIATED WITH IMPAIRED GLUCOSE TOLERANCE OR METABOLIC SYNDROME | SMITHKLINE BEECHAM CORPORATION | 2002-12-24 | — | — | US | disclosed |
| EP-1102757-A1 | SUBSTITUTED OXAZOLE AND THIAZOLE DERIVATIVES AS HPPAR GAMMA AND HPPAR ALPHA ACTIVATORS | GLAXO GROUP LIMITED (GB) | 2001-05-30 | — | — | EP | disclosed |
| WO-2000008002-A1 | SUBSTITUTED OXAZOLES AND THIAZOLES DERIVATIVES AS hPPAR GAMMA AND hPPAR ALPHA ACTIVATORS | GLAXO GROUP LIMITED (GB) | 2000-02-17 | — | — | WO | disclosed |