Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 17/20 | 0.71 |
| ▸ | HTR2C | P28335 | 1/20 | 0.63 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6604265 | 0.93 | MCHR1 (0.70) | MCHR1HTR2CHDAC1HDAC2 | |
| SCHEMBL6603140 | 0.88 | MCHR1 (0.54) | MCHR1HTR2CCYP1A2POLBCYP3A4 | |
| SCHEMBL6927129 | 0.87 | MCHR1 (0.93) | MCHR1HTR2CSLC2A1CYP1A2POLB | |
| SCHEMBL6605517 | 0.83 | KMT2A (0.68) | MCHR1HTR2C | |
| SCHEMBL6925443 | 0.83 | MCHR1 (0.81) | MCHR1HTR2CSLC2A1 | |
| SCHEMBL6603858 | 0.82 | MCHR1 (0.71) | MCHR1HTR2CSLC2A1 | |
| SCHEMBL6924013 | 0.82 | MCHR1 (0.71) | MCHR1HTR2CSLC2A1 | |
| SCHEMBL6894756 | 0.82 | MCHR1 (0.76) | MCHR1HTR2CSLC2A1 | |
| SCHEMBL6926340 | 0.81 | MCHR1 (0.92) | MCHR1HTR2CSLC2A1 | |
| SCHEMBL6930454 | 0.81 | MCHR1 (0.81) | MCHR1HTR2CSLC2A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1102535-A4 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORP (US) | 2004-09-29 | — | — | EP | claimed |
| EP-1102535-A2 | COMPOUNDS AND METHODS | SmithKline Beecham Corporation (US) | 2001-05-30 | — | — | EP | claimed |
| WO-2000006085-A2 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-02-10 | — | — | WO | claimed |
| EP-1102535-A4 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORP (US) | 2004-09-29 | — | — | EP | disclosed |
| US-6399656-B1 | USING A BENZOPYRAN-3-CARBOXAMIDE COMPOUND | SMITHKLINE BEECHAM CORPORATION | 2002-06-04 | — | — | US | disclosed |
| EP-1102535-A2 | COMPOUNDS AND METHODS | SmithKline Beecham Corporation (US) | 2001-05-30 | — | — | EP | disclosed |
| WO-2000006085-A2 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-02-10 | — | — | WO | disclosed |