Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 15/20 | 1.00 |
| ▸ | HTR1B | P28222 | 15/20 | 1.00 |
| ▸ | HTR1A | P08908 | 4/20 | 0.71 |
| ▸ | HTR2C | P28335 | 5/20 | 0.51 |
| ▸ | HTR2A | P28223 | 4/20 | 0.51 |
| ▸ | HTR2B | P41595 | 3/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6603248 | 1.00 | HTR1D (1.00) | HTR1DHTR1BHTR1AHTR2CHTR2A | |
| SCHEMBL6605000 | 0.93 | HTR1D (0.86) | HTR1DHTR1BHTR1AHTR2CHTR2A | |
| SCHEMBL6604995 | 0.93 | HTR1D (0.86) | HTR1DHTR1BHTR1AHTR2CHTR2A | |
| SCHEMBL6604792 | 0.91 | HTR1B (1.00) | HTR1DHTR1BHTR1AHTR2CHTR2A | |
| SCHEMBL6604787 | 0.91 | HTR1B (1.00) | HTR1DHTR1BHTR1AHTR2CHTR2A | |
| SCHEMBL6606501 | 0.89 | HTR1B (0.79) | HTR1DHTR1BHTR1AHTR2CHTR2A | |
| SCHEMBL6606502 | 0.89 | HTR1B (0.79) | HTR1DHTR1BHTR1AHTR2CHTR2A | |
| SCHEMBL6603798 | 0.88 | HTR1B (1.00) | HTR1DHTR1BHTR1AHTR2CHTR2A | |
| SCHEMBL6603805 | 0.88 | HTR1B (1.00) | HTR1DHTR1BHTR1AHTR2CHTR2A | |
| SCHEMBL6604237 | 0.84 | HTR1B (1.00) | HTR1DHTR1BHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1216239-B1 | PIPERAZINE DERIVATIVES AS 5-HT1B ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 2004-02-11 | — | — | EP | claimed |
| WO-2020183011-A1 | HTR1D INHIBITORS AND USES THEREOF IN THE TREATMENT OF CANCER | INSTITUT CURIE (FR) | 2020-09-17 | — | — | WO | disclosed |
| EP-1216239-B1 | PIPERAZINE DERIVATIVES AS 5-HT1B ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 2004-02-11 | — | — | EP | disclosed |