Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 9/20 | 0.69 |
| ▸ | HTR1B | P28222 | 9/20 | 0.69 |
| ▸ | HTR2A | P28223 | 5/20 | 0.69 |
| ▸ | MEN1 | O00255 | 2/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.69 |
| ▸ | TP53 | P04637 | 1/20 | 0.69 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.69 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.69 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.69 |
| ▸ | MAPT | P10636 | 1/20 | 0.69 |
| ▸ | HPGD | P15428 | 1/20 | 0.69 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.69 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.69 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.69 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.69 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.68 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.68 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8744156 | 0.89 | HTR1D (0.72) | HTR1DHTR1BHTR2AMEN1ALDH1A1 | |
| SCHEMBL8654316 | 0.89 | HTR1D (0.74) | HTR1DHTR1BHTR2AMEN1ALDH1A1 | |
| SCHEMBL8653043 | 0.88 | HTR1D (0.73) | HTR1DHTR1BHTR2AMEN1ALDH1A1 | |
| SCHEMBL7447318 | 0.88 | HTR1D (0.66) | HTR1DHTR1BHTR2AMEN1ALDH1A1 | |
| SCHEMBL7397448 | 0.85 | HTR1D (0.69) | HTR1DHTR1BHTR2AMEN1ALDH1A1 | |
| SCHEMBL7450572 | 0.85 | HTR1D (0.91) | HTR1DHTR1BHTR2AMEN1ALDH1A1 | |
| SCHEMBL8652789 | 0.85 | HTR1D (0.69) | HTR1DHTR1BHTR2AMEN1ALDH1A1 | |
| SCHEMBL8662120 | 0.85 | HTR1D (0.69) | HTR1DHTR1BHTR2AMEN1ALDH1A1 | |
| SCHEMBL8652792 | 0.85 | HTR1D (0.69) | HTR1DHTR1BHTR2AMEN1ALDH1A1 | |
| SCHEMBL8652262 | 0.84 | HTR1D (0.68) | HTR1DHTR1BHTR2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1102535-A4 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORP (US) | 2004-09-29 | — | — | EP | disclosed |
| US-6399656-B1 | USING A BENZOPYRAN-3-CARBOXAMIDE COMPOUND | SMITHKLINE BEECHAM CORPORATION | 2002-06-04 | — | — | US | disclosed |
| EP-1102535-A2 | COMPOUNDS AND METHODS | SmithKline Beecham Corporation (US) | 2001-05-30 | — | — | EP | disclosed |
| WO-2000006085-A2 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-02-10 | — | — | WO | disclosed |